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Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study
Family history (FH) is predictive of the development of major psychiatric disorders (PSY). Familial psychiatric disorders are largely a consequence of genetic factors and typically exhibit more severe impairments. Decreased prefrontal activity during verbal fluency testing (VFT) may constitute an in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353718/ https://www.ncbi.nlm.nih.gov/pubmed/28295013 http://dx.doi.org/10.1038/srep44268 |
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author | Ohi, Kazutaka Shimada, Takamitsu Kihara, Hiroaki Yasuyama, Toshiki Sawai, Kazuyuki Matsuda, Yukihisa Oshima, Kazuaki Okubo, Hiroaki Nitta, Yusuke Uehara, Takashi Kawasaki, Yasuhiro |
author_facet | Ohi, Kazutaka Shimada, Takamitsu Kihara, Hiroaki Yasuyama, Toshiki Sawai, Kazuyuki Matsuda, Yukihisa Oshima, Kazuaki Okubo, Hiroaki Nitta, Yusuke Uehara, Takashi Kawasaki, Yasuhiro |
author_sort | Ohi, Kazutaka |
collection | PubMed |
description | Family history (FH) is predictive of the development of major psychiatric disorders (PSY). Familial psychiatric disorders are largely a consequence of genetic factors and typically exhibit more severe impairments. Decreased prefrontal activity during verbal fluency testing (VFT) may constitute an intermediate phenotype for PSY. We investigated whether familial PSY were associated with a greater severity of prefrontal dysfunction in accordance with genetic loading. We measured prefrontal activity during VFT using near-infrared spectroscopy (NIRS) in patients with schizophrenia (SCZ, n = 45), major depressive disorder (MDD, n = 26) or bipolar disorder (BIP, n = 22) and healthy controls (HC, n = 51). We compared prefrontal activity among patients with or without FH and HC. Patients in the SCZ, MDD and BIP patient groups had lower prefrontal activity than HC subjects. Patients with and without FH in all diagnostic groups had lower prefrontal activity than HC subjects. Moreover, SCZ patients with FH had lower prefrontal activity than SCZ patients without FH. When we included patients with SCZ, MDD or BIP in the group of patients with PSY, the effects of psychiatric FH on prefrontal activity were enhanced. These findings demonstrate the association of substantially more severe prefrontal dysfunction with higher genetic loading in major psychiatric disorders. |
format | Online Article Text |
id | pubmed-5353718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53537182017-03-22 Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study Ohi, Kazutaka Shimada, Takamitsu Kihara, Hiroaki Yasuyama, Toshiki Sawai, Kazuyuki Matsuda, Yukihisa Oshima, Kazuaki Okubo, Hiroaki Nitta, Yusuke Uehara, Takashi Kawasaki, Yasuhiro Sci Rep Article Family history (FH) is predictive of the development of major psychiatric disorders (PSY). Familial psychiatric disorders are largely a consequence of genetic factors and typically exhibit more severe impairments. Decreased prefrontal activity during verbal fluency testing (VFT) may constitute an intermediate phenotype for PSY. We investigated whether familial PSY were associated with a greater severity of prefrontal dysfunction in accordance with genetic loading. We measured prefrontal activity during VFT using near-infrared spectroscopy (NIRS) in patients with schizophrenia (SCZ, n = 45), major depressive disorder (MDD, n = 26) or bipolar disorder (BIP, n = 22) and healthy controls (HC, n = 51). We compared prefrontal activity among patients with or without FH and HC. Patients in the SCZ, MDD and BIP patient groups had lower prefrontal activity than HC subjects. Patients with and without FH in all diagnostic groups had lower prefrontal activity than HC subjects. Moreover, SCZ patients with FH had lower prefrontal activity than SCZ patients without FH. When we included patients with SCZ, MDD or BIP in the group of patients with PSY, the effects of psychiatric FH on prefrontal activity were enhanced. These findings demonstrate the association of substantially more severe prefrontal dysfunction with higher genetic loading in major psychiatric disorders. Nature Publishing Group 2017-03-15 /pmc/articles/PMC5353718/ /pubmed/28295013 http://dx.doi.org/10.1038/srep44268 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Ohi, Kazutaka Shimada, Takamitsu Kihara, Hiroaki Yasuyama, Toshiki Sawai, Kazuyuki Matsuda, Yukihisa Oshima, Kazuaki Okubo, Hiroaki Nitta, Yusuke Uehara, Takashi Kawasaki, Yasuhiro Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study |
title | Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study |
title_full | Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study |
title_fullStr | Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study |
title_full_unstemmed | Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study |
title_short | Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study |
title_sort | impact of familial loading on prefrontal activation in major psychiatric disorders: a near-infrared spectroscopy (nirs) study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353718/ https://www.ncbi.nlm.nih.gov/pubmed/28295013 http://dx.doi.org/10.1038/srep44268 |
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