Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional regulatory mechanism of ACER2 gene and its potential role in the regulation of autophagy remain unknown. In this study, we...

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Detalles Bibliográficos
Autores principales: Wang, Yitao, Zhang, Chunxue, Jin, Yuelei, Wang, He, Qing, Liu, Zhu, Ai, Qing, Lei, Yunlong, Li, Yi, Song, Fangzhou, Bu, Youquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353723/
https://www.ncbi.nlm.nih.gov/pubmed/28294157
http://dx.doi.org/10.1038/srep44573

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