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Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to pa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353743/ https://www.ncbi.nlm.nih.gov/pubmed/28300224 http://dx.doi.org/10.1038/srep44741 |
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author | Lee, Hyewon Myung, Woojae Kim, Doh Kwan Kim, Satbyul Estella Kim, Clara Tammy Kim, Ho |
author_facet | Lee, Hyewon Myung, Woojae Kim, Doh Kwan Kim, Satbyul Estella Kim, Clara Tammy Kim, Ho |
author_sort | Lee, Hyewon |
collection | PubMed |
description | Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to particles <2.5 μm (PM(2.5)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), ozone (O(3)), and carbon monoxide (CO) with PD aggravation in Seoul from the National Health Insurance Service–National Sample Cohort, Korea during 2002–2013. PD aggravation cases were defined as emergency hospital admissions for primarily diagnosed PD and analyzed with a case-crossover analysis, designed for rare acute outcomes. Pollutants concentrations on case and control days were compared and effect modifications were explored. A unit increase in 8-day moving average of concentrations was significantly associated with PD aggravation. The association was consistent for PM(2.5) (odds ratio [95% confidence interval]: 1.61 [1.14–2.29] per 10 μg/m(3)), NO(2) (2.35 [1.39–3.97] per 10 ppb), SO(2) (1.54 [1.11–2.14] per 1 ppb), and CO (1.46 [1.05–2.04] per 0.1 ppm). The associations were stronger in women, patients aged 65–74 years, and cold season, but not significant. In conclusion, short-term air pollution exposure increased risk of PD aggravation, and may cause neurological disease progression in humans. |
format | Online Article Text |
id | pubmed-5353743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53537432017-03-22 Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort Lee, Hyewon Myung, Woojae Kim, Doh Kwan Kim, Satbyul Estella Kim, Clara Tammy Kim, Ho Sci Rep Article Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to particles <2.5 μm (PM(2.5)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), ozone (O(3)), and carbon monoxide (CO) with PD aggravation in Seoul from the National Health Insurance Service–National Sample Cohort, Korea during 2002–2013. PD aggravation cases were defined as emergency hospital admissions for primarily diagnosed PD and analyzed with a case-crossover analysis, designed for rare acute outcomes. Pollutants concentrations on case and control days were compared and effect modifications were explored. A unit increase in 8-day moving average of concentrations was significantly associated with PD aggravation. The association was consistent for PM(2.5) (odds ratio [95% confidence interval]: 1.61 [1.14–2.29] per 10 μg/m(3)), NO(2) (2.35 [1.39–3.97] per 10 ppb), SO(2) (1.54 [1.11–2.14] per 1 ppb), and CO (1.46 [1.05–2.04] per 0.1 ppm). The associations were stronger in women, patients aged 65–74 years, and cold season, but not significant. In conclusion, short-term air pollution exposure increased risk of PD aggravation, and may cause neurological disease progression in humans. Nature Publishing Group 2017-03-16 /pmc/articles/PMC5353743/ /pubmed/28300224 http://dx.doi.org/10.1038/srep44741 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lee, Hyewon Myung, Woojae Kim, Doh Kwan Kim, Satbyul Estella Kim, Clara Tammy Kim, Ho Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort |
title | Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort |
title_full | Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort |
title_fullStr | Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort |
title_full_unstemmed | Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort |
title_short | Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort |
title_sort | short-term air pollution exposure aggravates parkinson’s disease in a population-based cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353743/ https://www.ncbi.nlm.nih.gov/pubmed/28300224 http://dx.doi.org/10.1038/srep44741 |
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