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Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort

Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to pa...

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Autores principales: Lee, Hyewon, Myung, Woojae, Kim, Doh Kwan, Kim, Satbyul Estella, Kim, Clara Tammy, Kim, Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353743/
https://www.ncbi.nlm.nih.gov/pubmed/28300224
http://dx.doi.org/10.1038/srep44741
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author Lee, Hyewon
Myung, Woojae
Kim, Doh Kwan
Kim, Satbyul Estella
Kim, Clara Tammy
Kim, Ho
author_facet Lee, Hyewon
Myung, Woojae
Kim, Doh Kwan
Kim, Satbyul Estella
Kim, Clara Tammy
Kim, Ho
author_sort Lee, Hyewon
collection PubMed
description Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to particles <2.5 μm (PM(2.5)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), ozone (O(3)), and carbon monoxide (CO) with PD aggravation in Seoul from the National Health Insurance Service–National Sample Cohort, Korea during 2002–2013. PD aggravation cases were defined as emergency hospital admissions for primarily diagnosed PD and analyzed with a case-crossover analysis, designed for rare acute outcomes. Pollutants concentrations on case and control days were compared and effect modifications were explored. A unit increase in 8-day moving average of concentrations was significantly associated with PD aggravation. The association was consistent for PM(2.5) (odds ratio [95% confidence interval]: 1.61 [1.14–2.29] per 10 μg/m(3)), NO(2) (2.35 [1.39–3.97] per 10 ppb), SO(2) (1.54 [1.11–2.14] per 1 ppb), and CO (1.46 [1.05–2.04] per 0.1 ppm). The associations were stronger in women, patients aged 65–74 years, and cold season, but not significant. In conclusion, short-term air pollution exposure increased risk of PD aggravation, and may cause neurological disease progression in humans.
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spelling pubmed-53537432017-03-22 Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort Lee, Hyewon Myung, Woojae Kim, Doh Kwan Kim, Satbyul Estella Kim, Clara Tammy Kim, Ho Sci Rep Article Increasing experimental evidence has suggested air pollution as new risk factor for neurological disease. Although long-term exposure is reportedly related to neurological disease, information on association with short-term exposure is scarce. We examined the association of short-term exposure to particles <2.5 μm (PM(2.5)), nitrogen dioxide (NO(2)), sulfur dioxide (SO(2)), ozone (O(3)), and carbon monoxide (CO) with PD aggravation in Seoul from the National Health Insurance Service–National Sample Cohort, Korea during 2002–2013. PD aggravation cases were defined as emergency hospital admissions for primarily diagnosed PD and analyzed with a case-crossover analysis, designed for rare acute outcomes. Pollutants concentrations on case and control days were compared and effect modifications were explored. A unit increase in 8-day moving average of concentrations was significantly associated with PD aggravation. The association was consistent for PM(2.5) (odds ratio [95% confidence interval]: 1.61 [1.14–2.29] per 10 μg/m(3)), NO(2) (2.35 [1.39–3.97] per 10 ppb), SO(2) (1.54 [1.11–2.14] per 1 ppb), and CO (1.46 [1.05–2.04] per 0.1 ppm). The associations were stronger in women, patients aged 65–74 years, and cold season, but not significant. In conclusion, short-term air pollution exposure increased risk of PD aggravation, and may cause neurological disease progression in humans. Nature Publishing Group 2017-03-16 /pmc/articles/PMC5353743/ /pubmed/28300224 http://dx.doi.org/10.1038/srep44741 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lee, Hyewon
Myung, Woojae
Kim, Doh Kwan
Kim, Satbyul Estella
Kim, Clara Tammy
Kim, Ho
Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
title Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
title_full Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
title_fullStr Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
title_full_unstemmed Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
title_short Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort
title_sort short-term air pollution exposure aggravates parkinson’s disease in a population-based cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353743/
https://www.ncbi.nlm.nih.gov/pubmed/28300224
http://dx.doi.org/10.1038/srep44741
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