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Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood–brain barrier following hypoxia-reoxygenation stress

BACKGROUND: Strategies to maintain BBB integrity in diseases with a hypoxia/reoxygenation (H/R) component involve preventing glutathione (GSH) loss from endothelial cells. GSH efflux transporters include multidrug resistance proteins (Mrps). Therefore, characterization of Mrp regulation at the BBB d...

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Detalles Bibliográficos
Autores principales:	Ibbotson, Kathryn, Yell, Joshua, Ronaldson, Patrick T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353788/ https://www.ncbi.nlm.nih.gov/pubmed/28298215 http://dx.doi.org/10.1186/s12987-017-0055-4

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