Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature

Methotrexate (MTX) is an antimetabolite used as a disease-modifying agent for various rheumatological conditions. We report two patients who were treated with daily low-dose MTX and developed acute interstitial pneumonitis requiring hospital admission. MTX-induced pneumonitis is a rare life-threaten...

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Autores principales: Iyyadurai, Ramya, Carey, Ronald Albert Benton, Satyendra, Sowmya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353835/
https://www.ncbi.nlm.nih.gov/pubmed/28349012
http://dx.doi.org/10.4103/2249-4863.201163
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author Iyyadurai, Ramya
Carey, Ronald Albert Benton
Satyendra, Sowmya
author_facet Iyyadurai, Ramya
Carey, Ronald Albert Benton
Satyendra, Sowmya
author_sort Iyyadurai, Ramya
collection PubMed
description Methotrexate (MTX) is an antimetabolite used as a disease-modifying agent for various rheumatological conditions. We report two patients who were treated with daily low-dose MTX and developed acute interstitial pneumonitis requiring hospital admission. MTX-induced pneumonitis is a rare life-threatening side effect, high index of clinical suspicion is required, treatment is mainly withdrawal of MTX, supportive therapy, and adjunctive steroids, outcome is good if condition is recognized early, and appropriate treatment is given.
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spelling pubmed-53538352017-03-27 Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature Iyyadurai, Ramya Carey, Ronald Albert Benton Satyendra, Sowmya J Family Med Prim Care Case Report Methotrexate (MTX) is an antimetabolite used as a disease-modifying agent for various rheumatological conditions. We report two patients who were treated with daily low-dose MTX and developed acute interstitial pneumonitis requiring hospital admission. MTX-induced pneumonitis is a rare life-threatening side effect, high index of clinical suspicion is required, treatment is mainly withdrawal of MTX, supportive therapy, and adjunctive steroids, outcome is good if condition is recognized early, and appropriate treatment is given. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5353835/ /pubmed/28349012 http://dx.doi.org/10.4103/2249-4863.201163 Text en Copyright: © 2017 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Iyyadurai, Ramya
Carey, Ronald Albert Benton
Satyendra, Sowmya
Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature
title Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature
title_full Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature
title_fullStr Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature
title_full_unstemmed Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature
title_short Low-dose methotrexate-induced acute interstitial pneumonitis: Report of two cases from South India and review of literature
title_sort low-dose methotrexate-induced acute interstitial pneumonitis: report of two cases from south india and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353835/
https://www.ncbi.nlm.nih.gov/pubmed/28349012
http://dx.doi.org/10.4103/2249-4863.201163
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AT satyendrasowmya lowdosemethotrexateinducedacuteinterstitialpneumonitisreportoftwocasesfromsouthindiaandreviewofliterature

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