Cargando…

A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients

Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces protein glycation and improves insulin sensitivity, while cumin is effective in remission of diabetes. Therefore this study was designed to evaluate the effects of vitamin E and cumin essential oil, on the blood le...

Descripción completa

Detalles Bibliográficos
Autores principales: Samani Keihan, Ghatreh, Gharib, Mohammad Hossein, Momeni, Ali, Hemati, Zohreh, Sedighin, Roya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353984/
https://www.ncbi.nlm.nih.gov/pubmed/28357199
_version_ 1782515242190766080
author Samani Keihan, Ghatreh
Gharib, Mohammad Hossein
Momeni, Ali
Hemati, Zohreh
Sedighin, Roya
author_facet Samani Keihan, Ghatreh
Gharib, Mohammad Hossein
Momeni, Ali
Hemati, Zohreh
Sedighin, Roya
author_sort Samani Keihan, Ghatreh
collection PubMed
description Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces protein glycation and improves insulin sensitivity, while cumin is effective in remission of diabetes. Therefore this study was designed to evaluate the effects of vitamin E and cumin essential oil, on the blood level of leptin,glycosylated hemoglobin (HbA1C) and also on lipid profile in diabetic patients.In this double blind clinical trial, 95 diabetic patients were selected and randomly dividedinto three groups.The first group received cumin essential oil in capsule form. The second group received Vitamin E, and the third group was used ascontrol receiving oral gelatin capsules as placebo for three months period.Blood glucose, lipid profile, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), leptin, HbA1c, oxidized LDL (oxLDL), and paraoxonase1 activity were measured. The results showed reduction in oxLDL and significant increase in paraoxonase 1 in Vitamin E group by the end of the third month period (P<0.05). Cumin group showed decrease in blood glucose, HbA1C, triglyceride, leptin and ox-LDL. ApoA1 and paraoxonase1 were also increased by cumin treatment (P<0.05).Diabetic complications may have been reduced by intake of Vitamin E and cumin essential oil. Cumin in comparison with vitamin E has broader impact and it is more beneficial in terms of ability to reduce the diabetic index.
format Online
Article
Text
id pubmed-5353984
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Babol University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-53539842017-03-29 A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients Samani Keihan, Ghatreh Gharib, Mohammad Hossein Momeni, Ali Hemati, Zohreh Sedighin, Roya Int J Mol Cell Med Original Article Diabetes is one of the most common metabolic diseases in the world. Vitamin E reduces protein glycation and improves insulin sensitivity, while cumin is effective in remission of diabetes. Therefore this study was designed to evaluate the effects of vitamin E and cumin essential oil, on the blood level of leptin,glycosylated hemoglobin (HbA1C) and also on lipid profile in diabetic patients.In this double blind clinical trial, 95 diabetic patients were selected and randomly dividedinto three groups.The first group received cumin essential oil in capsule form. The second group received Vitamin E, and the third group was used ascontrol receiving oral gelatin capsules as placebo for three months period.Blood glucose, lipid profile, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), leptin, HbA1c, oxidized LDL (oxLDL), and paraoxonase1 activity were measured. The results showed reduction in oxLDL and significant increase in paraoxonase 1 in Vitamin E group by the end of the third month period (P<0.05). Cumin group showed decrease in blood glucose, HbA1C, triglyceride, leptin and ox-LDL. ApoA1 and paraoxonase1 were also increased by cumin treatment (P<0.05).Diabetic complications may have been reduced by intake of Vitamin E and cumin essential oil. Cumin in comparison with vitamin E has broader impact and it is more beneficial in terms of ability to reduce the diabetic index. Babol University of Medical Sciences 2016 2017-01-24 /pmc/articles/PMC5353984/ /pubmed/28357199 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Samani Keihan, Ghatreh
Gharib, Mohammad Hossein
Momeni, Ali
Hemati, Zohreh
Sedighin, Roya
A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
title A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
title_full A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
title_fullStr A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
title_full_unstemmed A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
title_short A Comparison Between the Effect of Cuminum Cyminum and Vitamin E on the Level of Leptin, Paraoxonase 1, HbA1c and Oxidized LDL in Diabetic Patients
title_sort comparison between the effect of cuminum cyminum and vitamin e on the level of leptin, paraoxonase 1, hba1c and oxidized ldl in diabetic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353984/
https://www.ncbi.nlm.nih.gov/pubmed/28357199
work_keys_str_mv AT samanikeihanghatreh acomparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT gharibmohammadhossein acomparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT momeniali acomparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT hematizohreh acomparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT sedighinroya acomparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT samanikeihanghatreh comparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT gharibmohammadhossein comparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT momeniali comparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT hematizohreh comparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients
AT sedighinroya comparisonbetweentheeffectofcuminumcyminumandvitamineonthelevelofleptinparaoxonase1hba1candoxidizedldlindiabeticpatients