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Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome
BACKGROUND: Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. OBJECTIVES: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354005/ https://www.ncbi.nlm.nih.gov/pubmed/28207163 http://dx.doi.org/10.1111/jvim.14670 |
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author | Roy, M.‐F. Kwong, G.P.S. Lambert, J. Massie, S. Lockhart, S. |
author_facet | Roy, M.‐F. Kwong, G.P.S. Lambert, J. Massie, S. Lockhart, S. |
author_sort | Roy, M.‐F. |
collection | PubMed |
description | BACKGROUND: Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. OBJECTIVES: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. ANIMALS: A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. METHODS: Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. RESULTS: Each of the 4 SIRS criteria was associated with outcome in this population. Thirty‐one percent of emergency cases had 2 or more abnormal SIRS criteria on admission and were defined as SIRS cases. SIRS was associated with increased odds of death (odds ratio [OR] = 8.22; 95% CI, 4.61–15.18; P < .001), an effect mainly found for acute gastrointestinal cases. SIRS cases were assigned a SIRS score of 2, 3, or 4, according to the number of abnormal SIRS criteria fulfilled on admission, and SIRS3 and SIRS4 cases had increased odds of death compared to SIRS2 cases (OR = 4.45; 95% CI, 1.78–11.15; P = .002). A model of severe SIRS including the SIRS score, blood lactate concentration, and color of the mucous membranes best predicted outcome in this population of horses. CONCLUSIONS AND CLINICAL IMPORTANCE: Systemic inflammatory response syndrome is associated with an increased risk of death in adult horses presenting with acute gastrointestinal illnesses. The model of severe SIRS proposed in this study could be used to assess the status and prognosis of adult equine emergency admissions. |
format | Online Article Text |
id | pubmed-5354005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53540052017-03-22 Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome Roy, M.‐F. Kwong, G.P.S. Lambert, J. Massie, S. Lockhart, S. J Vet Intern Med EQUID BACKGROUND: Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown. OBJECTIVES: To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome. ANIMALS: A total of 479 consecutive adult horse emergency admissions to a private primary referral practice. METHODS: Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used. RESULTS: Each of the 4 SIRS criteria was associated with outcome in this population. Thirty‐one percent of emergency cases had 2 or more abnormal SIRS criteria on admission and were defined as SIRS cases. SIRS was associated with increased odds of death (odds ratio [OR] = 8.22; 95% CI, 4.61–15.18; P < .001), an effect mainly found for acute gastrointestinal cases. SIRS cases were assigned a SIRS score of 2, 3, or 4, according to the number of abnormal SIRS criteria fulfilled on admission, and SIRS3 and SIRS4 cases had increased odds of death compared to SIRS2 cases (OR = 4.45; 95% CI, 1.78–11.15; P = .002). A model of severe SIRS including the SIRS score, blood lactate concentration, and color of the mucous membranes best predicted outcome in this population of horses. CONCLUSIONS AND CLINICAL IMPORTANCE: Systemic inflammatory response syndrome is associated with an increased risk of death in adult horses presenting with acute gastrointestinal illnesses. The model of severe SIRS proposed in this study could be used to assess the status and prognosis of adult equine emergency admissions. John Wiley and Sons Inc. 2017-02-16 2017 /pmc/articles/PMC5354005/ /pubmed/28207163 http://dx.doi.org/10.1111/jvim.14670 Text en Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | EQUID Roy, M.‐F. Kwong, G.P.S. Lambert, J. Massie, S. Lockhart, S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
title | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
title_full | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
title_fullStr | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
title_full_unstemmed | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
title_short | Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome |
title_sort | prognostic value and development of a scoring system in horses with systemic inflammatory response syndrome |
topic | EQUID |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354005/ https://www.ncbi.nlm.nih.gov/pubmed/28207163 http://dx.doi.org/10.1111/jvim.14670 |
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