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Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06)
PURPOSE: To determine inter-observer variability in target volume definition of cervical cancer in radical and adjuvant radiotherapy (RT) settings. METHODS: Eight physicians contoured CTVs of 2 patients underwent definitive and postoperative RT. Each volume was analyzed using the individual/median v...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354274/ https://www.ncbi.nlm.nih.gov/pubmed/28301492 http://dx.doi.org/10.1371/journal.pone.0173476 |
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author | Joo, Ji Hyeon Kim, Young Seok Cho, Byung Chul Jeong, Chi Young Park, Won Kim, Hak Jae Yoon, Won Sup Yoon, Mee Sun Kim, Ji-Yoon Choi, Jin Hwa Choi, Youngmin Kim, Joo-Young |
author_facet | Joo, Ji Hyeon Kim, Young Seok Cho, Byung Chul Jeong, Chi Young Park, Won Kim, Hak Jae Yoon, Won Sup Yoon, Mee Sun Kim, Ji-Yoon Choi, Jin Hwa Choi, Youngmin Kim, Joo-Young |
author_sort | Joo, Ji Hyeon |
collection | PubMed |
description | PURPOSE: To determine inter-observer variability in target volume definition of cervical cancer in radical and adjuvant radiotherapy (RT) settings. METHODS: Eight physicians contoured CTVs of 2 patients underwent definitive and postoperative RT. Each volume was analyzed using the individual/median volume ratio and generalized conformity index (CI(gen)). And center of mass (COM) of each contour was calculated. Expert agreement was quantified using an expectation maximization algorithm for Simultaneous Truth and Performance Level Estimation (STAPLE). RESULTS: For definitive RT, the individual/median volume ratio ranged from 0.51 to 1.41, and CI(gen) was 0.531. Mean 3-dimensional distances of average to each COM were 7.8 mm. For postoperative RT setting, corresponding values were 0.65–1.38, 0.563, and 5.3 mm. Kappa value of expert agreement was 0.65 and 0.67, respectively. STAPLE estimates of the sensitivity, specificity, and kappa measures of inter-physician agreement were 0.73, 0.98, and 0.65 for the definitive and 0.75, 0.98, and 0.67 for the adjuvant radiotherapy setting. The largest difference was observed in the superior-inferior direction, particularly in the upper vagina and the common iliac area. CONCLUSION: As there was still some variability in target delineation, more detailed guidelines for target volume delineation and continuing education would help to reduce this uncertainty. |
format | Online Article Text |
id | pubmed-5354274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53542742017-04-06 Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) Joo, Ji Hyeon Kim, Young Seok Cho, Byung Chul Jeong, Chi Young Park, Won Kim, Hak Jae Yoon, Won Sup Yoon, Mee Sun Kim, Ji-Yoon Choi, Jin Hwa Choi, Youngmin Kim, Joo-Young PLoS One Research Article PURPOSE: To determine inter-observer variability in target volume definition of cervical cancer in radical and adjuvant radiotherapy (RT) settings. METHODS: Eight physicians contoured CTVs of 2 patients underwent definitive and postoperative RT. Each volume was analyzed using the individual/median volume ratio and generalized conformity index (CI(gen)). And center of mass (COM) of each contour was calculated. Expert agreement was quantified using an expectation maximization algorithm for Simultaneous Truth and Performance Level Estimation (STAPLE). RESULTS: For definitive RT, the individual/median volume ratio ranged from 0.51 to 1.41, and CI(gen) was 0.531. Mean 3-dimensional distances of average to each COM were 7.8 mm. For postoperative RT setting, corresponding values were 0.65–1.38, 0.563, and 5.3 mm. Kappa value of expert agreement was 0.65 and 0.67, respectively. STAPLE estimates of the sensitivity, specificity, and kappa measures of inter-physician agreement were 0.73, 0.98, and 0.65 for the definitive and 0.75, 0.98, and 0.67 for the adjuvant radiotherapy setting. The largest difference was observed in the superior-inferior direction, particularly in the upper vagina and the common iliac area. CONCLUSION: As there was still some variability in target delineation, more detailed guidelines for target volume delineation and continuing education would help to reduce this uncertainty. Public Library of Science 2017-03-16 /pmc/articles/PMC5354274/ /pubmed/28301492 http://dx.doi.org/10.1371/journal.pone.0173476 Text en © 2017 Joo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Joo, Ji Hyeon Kim, Young Seok Cho, Byung Chul Jeong, Chi Young Park, Won Kim, Hak Jae Yoon, Won Sup Yoon, Mee Sun Kim, Ji-Yoon Choi, Jin Hwa Choi, Youngmin Kim, Joo-Young Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) |
title | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) |
title_full | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) |
title_fullStr | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) |
title_full_unstemmed | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) |
title_short | Variability in target delineation of cervical carcinoma: A Korean radiation oncology group study (KROG 15-06) |
title_sort | variability in target delineation of cervical carcinoma: a korean radiation oncology group study (krog 15-06) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354274/ https://www.ncbi.nlm.nih.gov/pubmed/28301492 http://dx.doi.org/10.1371/journal.pone.0173476 |
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