Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability

A facultative heterochromatin mark, histone H3 lysine 9 dimethylation (H3K9me2), which is mediated by histone methyltransferases G9a/GLP (EHMT2/1), undergoes dramatic rearrangements during myeloid cell differentiation as observed by chromatin imaging. To determine whether these structural transition...

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Detalles Bibliográficos
Autores principales: Salzberg, Anna C., Harris-Becker, Abigail, Popova, Evgenya Y., Keasey, Nikki, Loughran, Thomas P., Claxton, David F., Grigoryev, Sergei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354391/
https://www.ncbi.nlm.nih.gov/pubmed/28301528
http://dx.doi.org/10.1371/journal.pone.0173723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354391/
https://www.ncbi.nlm.nih.gov/pubmed/28301528
http://dx.doi.org/10.1371/journal.pone.0173723

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