Cargando…

Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway

Human parvovirus B19 (B19V) infection of primary human erythroid progenitor cells (EPCs) arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR) that facilitates viral DNA replication but is dispensable for cell cycle arrest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Peng, Zhou, Zhe, Xiong, Min, Zou, Wei, Deng, Xuefeng, Ganaie, Safder S., Kleiboeker, Steve, Peng, Jianxin, Liu, Kaiyu, Wang, Shengqi, Ye, Shui Qing, Qiu, Jianming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354443/ https://www.ncbi.nlm.nih.gov/pubmed/28264028 http://dx.doi.org/10.1371/journal.ppat.1006266

Ejemplares similares

Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex
por: Ganaie, Safder S., et al.
Publicado: (2017)

Recent Advances in Replication and Infection of Human Parvovirus B19
por: Ganaie, Safder S., et al.
Publicado: (2018)

RNA Binding Motif Protein RBM45 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19 through Binding to Novel Intron Splicing Enhancers
por: Wang, Jianke, et al.
Publicado: (2020)

Establishment of a Parvovirus B19 NS1-Expressing Recombinant Adenoviral Vector for Killing Megakaryocytic Leukemia Cells
por: Xu, Peng, et al.
Publicado: (2019)

The Putative Metal Coordination Motif in the Endonuclease Domain of Human Parvovirus B19 NS1 Is Critical for NS1 Induced S Phase Arrest and DNA Damage
por: Kivovich, Violetta, et al.
Publicado: (2011)

ATR Inhibition Induces CDK1–SPOP Signaling and Enhances Anti–PD-L1 Cytotoxicity in Prostate Cancer
por: Tang, Zhe, et al.
Publicado: (2021)

Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors
por: Ning, Kang, et al.
Publicado: (2023)

Productive Parvovirus B19 Infection of Primary Human Erythroid Progenitor Cells at Hypoxia Is Regulated by STAT5A and MEK Signaling but not HIFα
por: Chen, Aaron Yun, et al.
Publicado: (2011)

PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors
por: Göder, Anja, et al.
Publicado: (2023)

Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein
por: Zhang, Yixi, et al.
Publicado: (2022)

The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory Diseases
por: Jalali, Sedigheh, et al.
Publicado: (2022)

Characterization of Natural Compounds as Inhibitors of NS1 Endonuclease from Canine Parvovirus Type 2
por: Kwak, So-Hyung, et al.
Publicado: (2023)

Sodium fluoride causes hepatocellular S-phase arrest by activating ATM-p53-p21 and ATR-Chk1-Cdc25A pathways in mice
por: Liu, Huan, et al.
Publicado: (2017)

Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28
por: Zimmermann, Christine, et al.
Publicado: (2017)

Cdk2 and Cdk4 cooperatively control the expression of Cdc2
por: Berthet, Cyril, et al.
Publicado: (2006)

CDK1 and CDC20 overexpression in patients with colorectal cancer are associated with poor prognosis: evidence from integrated bioinformatics analysis
por: Li, Jianxin, et al.
Publicado: (2020)

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13
por: Tseng, Shun-Fu, et al.
Publicado: (2009)

The NS1 protein of the parvovirus MVM Aids in the localization of the viral genome to cellular sites of DNA damage
por: Majumder, Kinjal, et al.
Publicado: (2020)

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells
por: Chen, Sansan, et al.
Publicado: (2016)

Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation
por: Shen, Tao, et al.
Publicado: (2018)

Cyclin A–CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry
por: Ng, Lau Yan, et al.
Publicado: (2023)

Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells
por: Bai, Bingjun, et al.
Publicado: (2020)

Performance of NS3, NS5a AND NS5b Hepatitis C Virus (HCV) Antiviral Resistance Sequencing Assays
por: Nutt, Jamie, et al.
Publicado: (2017)

Human Parvovirus B19 NS1 Protein Aggravates Liver Injury in NZB/W F1 Mice
por: Tsai, Chun-Chou, et al.
Publicado: (2013)

Exacerbating Effects of Human Parvovirus B19 NS1 on Liver Fibrosis in NZB/W F1 Mice
por: Hsu, Tsai-Ching, et al.
Publicado: (2013)

Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae
por: Enserink, Jorrit M., et al.
Publicado: (2009)

Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein's Cytotoxicity in Culture
por: Kivovich, Violetta, et al.
Publicado: (2010)

Celastrol attenuates human parvovirus B19 NS1‑induced NLRP3 inflammasome activation in macrophages
por: Huang, Chang-Lun, et al.
Publicado: (2023)

Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
por: Landsverk, Helga B, et al.
Publicado: (2019)

SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation
por: Chen, Songbiao, et al.
Publicado: (2021)

Biology of Porcine Parvovirus (Ungulate parvovirus 1)
por: Mészáros, István, et al.
Publicado: (2017)

Editorial: Virus-induced innate immune response and inflammation
por: Ganaie, Safder S., et al.
Publicado: (2023)

Correction: Exacerbating Effects of Human Parvovirus B19 NS1 on Liver Fibrosis in NZB/W F1 Mice
por: Hsu, Tsai-Ching, et al.
Publicado: (2014)

The Autonomous Parvovirus Minute Virus of Mice Localizes to Cellular Sites of DNA Damage Using ATR Signaling
por: Larsen, Clairine I. S., et al.
Publicado: (2023)

The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest
por: Ma, Hanhui, et al.
Publicado: (2013)

ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma
por: Georgiou, Marina, et al.
Publicado: (2022)

Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCF(Cdc4) recognition in Saccharomyces cerevisiae
por: Al-Zain, Amr, et al.
Publicado: (2015)

The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia
por: Shao, Liting, et al.
Publicado: (2022)

The Determinants for the Enzyme Activity of Human Parvovirus B19 Phospholipase A2 (PLA2) and Its Influence on Cultured Cells
por: Deng, Xuefeng, et al.
Publicado: (2013)

Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway
por: Jin, Xiaohui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5890p2kqr09taih854drdslq66