Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes exclusively transcribes ribosomal RNA genes (rDNA)....

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Detalles Bibliográficos
Autores principales: Kerry, Louise E., Pegg, Elaine E., Cameron, Donald P., Budzak, James, Poortinga, Gretchen, Hannan, Katherine M., Hannan, Ross D., Rudenko, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354456/
https://www.ncbi.nlm.nih.gov/pubmed/28263991
http://dx.doi.org/10.1371/journal.pntd.0005432

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