OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations

Inhibitors targeting epigenetic control points of oncogenes offer a potential mean of blocking tumor progression in small cell and non-small cell lung carcinomas (SCLC, NSCLC). OTX015 (MK-8628) is a BET inhibitor selectively blocking BRD2/3/4. OTX015 was evaluated in a panel of NSCLC or SCLC models...

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Detalles Bibliográficos
Autores principales: Riveiro, Maria E., Astorgues-Xerri, Lucile, Vazquez, Ramiro, Frapolli, Roberta, Kwee, Ivo, Rinaldi, Andrea, Odore, Elodie, Rezai, Keyvan, Bekradda, Mohamed, Inghirami, Giorgio, D'Incalci, Maurizio, Noel, Kay, Cvitkovic, Esteban, Raymond, Eric, Bertoni, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354535/
https://www.ncbi.nlm.nih.gov/pubmed/27835869
http://dx.doi.org/10.18632/oncotarget.13181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354535/
https://www.ncbi.nlm.nih.gov/pubmed/27835869
http://dx.doi.org/10.18632/oncotarget.13181

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