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EzrA: a spectrin-like scaffold in the bacterial cell division machinery

Much progress has been made in identifying the components of the divisome, the assembly of proteins that undertakes the vital process of cell division in bacteria. However, how the highly interdependent processes on either side of the membrane are coordinated during division is a major unresolved qu...

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Autores principales: Cleverley, Robert, Lewis, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354558/
https://www.ncbi.nlm.nih.gov/pubmed/28357277
http://dx.doi.org/10.15698/mic2015.02.187
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author Cleverley, Robert
Lewis, Richard
author_facet Cleverley, Robert
Lewis, Richard
author_sort Cleverley, Robert
collection PubMed
description Much progress has been made in identifying the components of the divisome, the assembly of proteins that undertakes the vital process of cell division in bacteria. However, how the highly interdependent processes on either side of the membrane are coordinated during division is a major unresolved question. How is the degradation and synthesis of the cell wall on the outside of the cell coordinated with cytokinesis and membrane fission, which are driven from the inside of the cell by the tubulin homologue FtsZ? A possible key mediator of such coordination is the membrane protein EzrA, as it interacts both with FtsZ and the penicillin binding proteins (PBPs) that synthesize peptidoglycan. Cleverley et al. [Nature Communications (2014) 5, 5421] have recently solved the crystal structure of the cytoplasmic domain of B. subtilis EzrA, which points to an important scaffolding role for EzrA in the divisome. The structure resembles the eukaryotic, cytoskeletal spectrin proteins, which link actin filaments in the cytoskeleton and also connect the actin cytoskeleton to membrane-bound integrin proteins.
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spelling pubmed-53545582017-03-29 EzrA: a spectrin-like scaffold in the bacterial cell division machinery Cleverley, Robert Lewis, Richard Microb Cell Microbiology Much progress has been made in identifying the components of the divisome, the assembly of proteins that undertakes the vital process of cell division in bacteria. However, how the highly interdependent processes on either side of the membrane are coordinated during division is a major unresolved question. How is the degradation and synthesis of the cell wall on the outside of the cell coordinated with cytokinesis and membrane fission, which are driven from the inside of the cell by the tubulin homologue FtsZ? A possible key mediator of such coordination is the membrane protein EzrA, as it interacts both with FtsZ and the penicillin binding proteins (PBPs) that synthesize peptidoglycan. Cleverley et al. [Nature Communications (2014) 5, 5421] have recently solved the crystal structure of the cytoplasmic domain of B. subtilis EzrA, which points to an important scaffolding role for EzrA in the divisome. The structure resembles the eukaryotic, cytoskeletal spectrin proteins, which link actin filaments in the cytoskeleton and also connect the actin cytoskeleton to membrane-bound integrin proteins. Shared Science Publishers OG 2015-01-15 /pmc/articles/PMC5354558/ /pubmed/28357277 http://dx.doi.org/10.15698/mic2015.02.187 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microbiology
Cleverley, Robert
Lewis, Richard
EzrA: a spectrin-like scaffold in the bacterial cell division machinery
title EzrA: a spectrin-like scaffold in the bacterial cell division machinery
title_full EzrA: a spectrin-like scaffold in the bacterial cell division machinery
title_fullStr EzrA: a spectrin-like scaffold in the bacterial cell division machinery
title_full_unstemmed EzrA: a spectrin-like scaffold in the bacterial cell division machinery
title_short EzrA: a spectrin-like scaffold in the bacterial cell division machinery
title_sort ezra: a spectrin-like scaffold in the bacterial cell division machinery
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354558/
https://www.ncbi.nlm.nih.gov/pubmed/28357277
http://dx.doi.org/10.15698/mic2015.02.187
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AT lewisrichard ezraaspectrinlikescaffoldinthebacterialcelldivisionmachinery