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Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)

Diphthamide is a highly conserved modification of archaeal and eukaryal translation elongation factor 2 (EF2) and yet why cells need EF2 to contain diphthamide is unclear. In yeast, the first steps of diphthamide synthesis and the genes (DPH1-DPH5) required to form the intermediate diphthine are wel...

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Detalles Bibliográficos
Autores principales:	Schaffrath, Raffael, Stark, Michael J. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2014
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354562/ https://www.ncbi.nlm.nih.gov/pubmed/28357244 http://dx.doi.org/10.15698/mic2014.06.151

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