Genome evolution in yeast reveals connections between rare mutations in human cancers

Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485-494] provides hard evidence that single gene deletions/mutati...

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Detalles Bibliográficos
Autores principales: Teng, Xinchen, Hardwick, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354563/
https://www.ncbi.nlm.nih.gov/pubmed/28357245
http://dx.doi.org/10.15698/mic2014.06.153
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author Teng, Xinchen
Hardwick, J. M.
author_facet Teng, Xinchen
Hardwick, J. M.
author_sort Teng, Xinchen
collection PubMed
description Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485-494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.
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spelling pubmed-53545632017-03-29 Genome evolution in yeast reveals connections between rare mutations in human cancers Teng, Xinchen Hardwick, J. M. Microb Cell Microbiology Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Teng et al. [Mol. Cell (2013) 52: 485-494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations. Shared Science Publishers OG 2014-06-02 /pmc/articles/PMC5354563/ /pubmed/28357245 http://dx.doi.org/10.15698/mic2014.06.153 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microbiology
Teng, Xinchen
Hardwick, J. M.
Genome evolution in yeast reveals connections between rare mutations in human cancers
title Genome evolution in yeast reveals connections between rare mutations in human cancers
title_full Genome evolution in yeast reveals connections between rare mutations in human cancers
title_fullStr Genome evolution in yeast reveals connections between rare mutations in human cancers
title_full_unstemmed Genome evolution in yeast reveals connections between rare mutations in human cancers
title_short Genome evolution in yeast reveals connections between rare mutations in human cancers
title_sort genome evolution in yeast reveals connections between rare mutations in human cancers
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354563/
https://www.ncbi.nlm.nih.gov/pubmed/28357245
http://dx.doi.org/10.15698/mic2014.06.153
work_keys_str_mv AT tengxinchen genomeevolutioninyeastrevealsconnectionsbetweenraremutationsinhumancancers
AT hardwickjm genomeevolutioninyeastrevealsconnectionsbetweenraremutationsinhumancancers

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