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Histone modifications as regulators of life and death in Saccharomyces cerevisiae
Apoptosis or programmed cell death is an integrated, genetically controlled suicide program that not only regulates tissue homeostasis of multicellular organisms, but also the fate of damaged and aged cells of lower eukaryotes, such as the yeast Saccharomyces cerevisiae. Recent years have revealed k...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Shared Science Publishers OG
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354586/ https://www.ncbi.nlm.nih.gov/pubmed/28357312 http://dx.doi.org/10.15698/mic2016.01.472 |
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author | Fahrenkrog, Birthe |
author_facet | Fahrenkrog, Birthe |
author_sort | Fahrenkrog, Birthe |
collection | PubMed |
description | Apoptosis or programmed cell death is an integrated, genetically controlled suicide program that not only regulates tissue homeostasis of multicellular organisms, but also the fate of damaged and aged cells of lower eukaryotes, such as the yeast Saccharomyces cerevisiae. Recent years have revealed key apoptosis regulatory proteins in yeast that play similar roles in mammalian cells. Apoptosis is a process largely defined by characteristic structural rearrangements in the dying cell that include chromatin condensation and DNA fragmentation. The mechanism by which chromosomes restructure during apoptosis is still poorly understood, but it is becoming increasingly clear that altered epigenetic histone modifications are fundamental parameters that influence the chromatin state and the nuclear rearrangements within apoptotic cells. The present review will highlight recent work on the epigenetic regulation of programmed cell death in budding yeast. |
format | Online Article Text |
id | pubmed-5354586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-53545862017-03-29 Histone modifications as regulators of life and death in Saccharomyces cerevisiae Fahrenkrog, Birthe Microb Cell Microbiology Apoptosis or programmed cell death is an integrated, genetically controlled suicide program that not only regulates tissue homeostasis of multicellular organisms, but also the fate of damaged and aged cells of lower eukaryotes, such as the yeast Saccharomyces cerevisiae. Recent years have revealed key apoptosis regulatory proteins in yeast that play similar roles in mammalian cells. Apoptosis is a process largely defined by characteristic structural rearrangements in the dying cell that include chromatin condensation and DNA fragmentation. The mechanism by which chromosomes restructure during apoptosis is still poorly understood, but it is becoming increasingly clear that altered epigenetic histone modifications are fundamental parameters that influence the chromatin state and the nuclear rearrangements within apoptotic cells. The present review will highlight recent work on the epigenetic regulation of programmed cell death in budding yeast. Shared Science Publishers OG 2015-12-31 /pmc/articles/PMC5354586/ /pubmed/28357312 http://dx.doi.org/10.15698/mic2016.01.472 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
spellingShingle | Microbiology Fahrenkrog, Birthe Histone modifications as regulators of life and death in Saccharomyces cerevisiae |
title | Histone modifications as regulators of life and death in
Saccharomyces cerevisiae |
title_full | Histone modifications as regulators of life and death in
Saccharomyces cerevisiae |
title_fullStr | Histone modifications as regulators of life and death in
Saccharomyces cerevisiae |
title_full_unstemmed | Histone modifications as regulators of life and death in
Saccharomyces cerevisiae |
title_short | Histone modifications as regulators of life and death in
Saccharomyces cerevisiae |
title_sort | histone modifications as regulators of life and death in
saccharomyces cerevisiae |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354586/ https://www.ncbi.nlm.nih.gov/pubmed/28357312 http://dx.doi.org/10.15698/mic2016.01.472 |
work_keys_str_mv | AT fahrenkrogbirthe histonemodificationsasregulatorsoflifeanddeathinsaccharomycescerevisiae |