Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging

Adaptive responses to stress, including hormesis, have been implicated in longevity, but their mechanisms and outcomes are not fully understood. Here, I briefly summarize a longevity mechanism elucidated in the budding yeast chronological lifespan model by which Mitochondrial Adaptive ROS Signaling...

Descripción completa

Detalles Bibliográficos
Autor principal: Shadel, Gerald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354597/
https://www.ncbi.nlm.nih.gov/pubmed/28357235
http://dx.doi.org/10.15698/mic2014.05.143
_version_ 1782515342041415680
author Shadel, Gerald S.
author_facet Shadel, Gerald S.
author_sort Shadel, Gerald S.
collection PubMed
description Adaptive responses to stress, including hormesis, have been implicated in longevity, but their mechanisms and outcomes are not fully understood. Here, I briefly summarize a longevity mechanism elucidated in the budding yeast chronological lifespan model by which Mitochondrial Adaptive ROS Signaling (MARS) promotes beneficial epigenetic and metabolic remodeling. The potential relevance of MARS to the human disease Ataxia-Telangiectasia and as a potential anti-aging target is discussed.
format Online
Article
Text
id pubmed-5354597
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Shared Science Publishers OG
record_format MEDLINE/PubMed
spelling pubmed-53545972017-03-29 Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging Shadel, Gerald S. Microb Cell Microbiology Adaptive responses to stress, including hormesis, have been implicated in longevity, but their mechanisms and outcomes are not fully understood. Here, I briefly summarize a longevity mechanism elucidated in the budding yeast chronological lifespan model by which Mitochondrial Adaptive ROS Signaling (MARS) promotes beneficial epigenetic and metabolic remodeling. The potential relevance of MARS to the human disease Ataxia-Telangiectasia and as a potential anti-aging target is discussed. Shared Science Publishers OG 2014-04-23 /pmc/articles/PMC5354597/ /pubmed/28357235 http://dx.doi.org/10.15698/mic2014.05.143 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microbiology
Shadel, Gerald S.
Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
title Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
title_full Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
title_fullStr Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
title_full_unstemmed Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
title_short Live longer on MARS: a yeast paradigm of mitochondrial adaptive ROS signaling in aging
title_sort live longer on mars: a yeast paradigm of mitochondrial adaptive ros signaling in aging
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354597/
https://www.ncbi.nlm.nih.gov/pubmed/28357235
http://dx.doi.org/10.15698/mic2014.05.143
work_keys_str_mv AT shadelgeralds livelongeronmarsayeastparadigmofmitochondrialadaptiverossignalinginaging

Ejemplares similares