Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect...

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Autores principales: Chen, Shaodan, Li, Xiangmin, Yong, Tianqiao, Wang, Zhanggen, Su, Jiyan, Jiao, Chunwei, Xie, Yizhen, Yang, Burton B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354642/
https://www.ncbi.nlm.nih.gov/pubmed/28052025
http://dx.doi.org/10.18632/oncotarget.14336
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author Chen, Shaodan
Li, Xiangmin
Yong, Tianqiao
Wang, Zhanggen
Su, Jiyan
Jiao, Chunwei
Xie, Yizhen
Yang, Burton B.
author_facet Chen, Shaodan
Li, Xiangmin
Yong, Tianqiao
Wang, Zhanggen
Su, Jiyan
Jiao, Chunwei
Xie, Yizhen
Yang, Burton B.
author_sort Chen, Shaodan
collection PubMed
description We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure–activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio. These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a theoretical foundation for designing novel therapeutic compounds.
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spelling pubmed-53546422017-04-14 Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships Chen, Shaodan Li, Xiangmin Yong, Tianqiao Wang, Zhanggen Su, Jiyan Jiao, Chunwei Xie, Yizhen Yang, Burton B. Oncotarget Research Paper We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure–activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio. These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a theoretical foundation for designing novel therapeutic compounds. Impact Journals LLC 2016-12-28 /pmc/articles/PMC5354642/ /pubmed/28052025 http://dx.doi.org/10.18632/oncotarget.14336 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chen, Shaodan
Li, Xiangmin
Yong, Tianqiao
Wang, Zhanggen
Su, Jiyan
Jiao, Chunwei
Xie, Yizhen
Yang, Burton B.
Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
title Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
title_full Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
title_fullStr Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
title_full_unstemmed Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
title_short Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure–activity relationships
title_sort cytotoxic lanostane-type triterpenoids from the fruiting bodies of ganoderma lucidum and their structure–activity relationships
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354642/
https://www.ncbi.nlm.nih.gov/pubmed/28052025
http://dx.doi.org/10.18632/oncotarget.14336
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