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BRCA1-IRIS overexpression promotes and maintains the tumor initiating phenotype: implications for triple negative breast cancer early lesions

Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44(+)/CD24(-)/ALDH1(+) phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to...

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Detalles Bibliográficos
Autores principales:	Sinha, Abhilasha, Paul, Bibbin T., Sullivan, Lisa M., Sims, Hillary, Bastawisy, Ahmed El, Yousef, Hend F., Zekri, Abdel-Rahman N., Bahnassy, Abeer A., ElShamy, Wael M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354646/ https://www.ncbi.nlm.nih.gov/pubmed/28052035 http://dx.doi.org/10.18632/oncotarget.14357

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