VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma

Clear cell Renal Cell Carcinoma (ccRCC) formation is connected to functional loss of the von Hippel-Lindau (VHL) gene. Recent data identified its gene product, pVHL, as a multifunctional adaptor protein which interacts with HIFα subunits but also with the tumor suppressor p53. p53 is hardly expresse...

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Detalles Bibliográficos
Autores principales: Razafinjatovo, Caroline Fanja, Stiehl, Daniel, Deininger, Eva, Rechsteiner, Markus, Moch, Holger, Schraml, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354652/
https://www.ncbi.nlm.nih.gov/pubmed/28052007
http://dx.doi.org/10.18632/oncotarget.14372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354652/
https://www.ncbi.nlm.nih.gov/pubmed/28052007
http://dx.doi.org/10.18632/oncotarget.14372

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