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Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population
We analyzed the effects of single-nucleotide polymorphisms (SNPs) on laryngeal carcinoma (LC) risk and overall survival (OS) in 170 Chinese male LC patients followed for 10 years. After assessment of clinical characteristics (age, laryngectomy, neck dissection, tumor differentiation, TNM status), th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354656/ https://www.ncbi.nlm.nih.gov/pubmed/28052013 http://dx.doi.org/10.18632/oncotarget.14381 |
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author | Quan, Fang Zhang, Feipeng Bai, Yanxia Zhou, Long Yang, Hua Li, Bin Jin, Tianbo Li, Huajing Shao, Yuan |
author_facet | Quan, Fang Zhang, Feipeng Bai, Yanxia Zhou, Long Yang, Hua Li, Bin Jin, Tianbo Li, Huajing Shao, Yuan |
author_sort | Quan, Fang |
collection | PubMed |
description | We analyzed the effects of single-nucleotide polymorphisms (SNPs) on laryngeal carcinoma (LC) risk and overall survival (OS) in 170 Chinese male LC patients followed for 10 years. After assessment of clinical characteristics (age, laryngectomy, neck dissection, tumor differentiation, TNM status), the patients were genotyped for 24 SNPs associated with risk in multiple cancers. LC risk was assessed using log-rank test and Cox proportional hazard models. The median OS time was 48 months. By the follow-up deadline, OS was 41.2%. Kaplan-Meier analysis indicated 1-, 3-, and 5-year survival rates to be 84.7%, 57.2%, and 47.1%, respectively. Five LC clinicopathological characteristics, namely total laryngectomy (TL), low differentiation (LD), T3-T4, N1-N2, and clinical stage III-IV were associated with worse OS (HR: 2.35, p < 0.001; HR: 2.39, p = 0.02; HR: 2.17, p < 0.001; HR: 2.39, p < 0.001; and HR: 3.29, p < 0.001, respectively). Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively). |
format | Online Article Text |
id | pubmed-5354656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53546562017-04-14 Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population Quan, Fang Zhang, Feipeng Bai, Yanxia Zhou, Long Yang, Hua Li, Bin Jin, Tianbo Li, Huajing Shao, Yuan Oncotarget Research Paper We analyzed the effects of single-nucleotide polymorphisms (SNPs) on laryngeal carcinoma (LC) risk and overall survival (OS) in 170 Chinese male LC patients followed for 10 years. After assessment of clinical characteristics (age, laryngectomy, neck dissection, tumor differentiation, TNM status), the patients were genotyped for 24 SNPs associated with risk in multiple cancers. LC risk was assessed using log-rank test and Cox proportional hazard models. The median OS time was 48 months. By the follow-up deadline, OS was 41.2%. Kaplan-Meier analysis indicated 1-, 3-, and 5-year survival rates to be 84.7%, 57.2%, and 47.1%, respectively. Five LC clinicopathological characteristics, namely total laryngectomy (TL), low differentiation (LD), T3-T4, N1-N2, and clinical stage III-IV were associated with worse OS (HR: 2.35, p < 0.001; HR: 2.39, p = 0.02; HR: 2.17, p < 0.001; HR: 2.39, p < 0.001; and HR: 3.29, p < 0.001, respectively). Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively). Impact Journals LLC 2016-12-30 /pmc/articles/PMC5354656/ /pubmed/28052013 http://dx.doi.org/10.18632/oncotarget.14381 Text en Copyright: © 2017 Quan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Quan, Fang Zhang, Feipeng Bai, Yanxia Zhou, Long Yang, Hua Li, Bin Jin, Tianbo Li, Huajing Shao, Yuan Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population |
title | Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population |
title_full | Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population |
title_fullStr | Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population |
title_full_unstemmed | Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population |
title_short | Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population |
title_sort | association of genetic polymorphisms with laryngeal carcinoma prognosis in a chinese population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354656/ https://www.ncbi.nlm.nih.gov/pubmed/28052013 http://dx.doi.org/10.18632/oncotarget.14381 |
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