Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi’an area of China. Of the four S...

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Detalles Bibliográficos
Autores principales: Wu, Yifei, Yan, Mengdan, Li, Jing, Li, Jingjie, Chen, Zhengshuai, Chen, Peng, Li, Bin, Chen, Fulin, Jin, Tianbo, Chen, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354677/
https://www.ncbi.nlm.nih.gov/pubmed/28060765
http://dx.doi.org/10.18632/oncotarget.14451
Descripción
Sumario:Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi’an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the “T(rs10069690)A(rs2242652)”, “T(rs10069690)G(rs2242652)” haplotypes were associated with an increased risk of esophageal cancer, while the and “C(rs10069690)G(rs2242652)” haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.

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