Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer

Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi’an area of China. Of the four S...

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Autores principales: Wu, Yifei, Yan, Mengdan, Li, Jing, Li, Jingjie, Chen, Zhengshuai, Chen, Peng, Li, Bin, Chen, Fulin, Jin, Tianbo, Chen, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354677/
https://www.ncbi.nlm.nih.gov/pubmed/28060765
http://dx.doi.org/10.18632/oncotarget.14451
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author Wu, Yifei
Yan, Mengdan
Li, Jing
Li, Jingjie
Chen, Zhengshuai
Chen, Peng
Li, Bin
Chen, Fulin
Jin, Tianbo
Chen, Chao
author_facet Wu, Yifei
Yan, Mengdan
Li, Jing
Li, Jingjie
Chen, Zhengshuai
Chen, Peng
Li, Bin
Chen, Fulin
Jin, Tianbo
Chen, Chao
author_sort Wu, Yifei
collection PubMed
description Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi’an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the “T(rs10069690)A(rs2242652)”, “T(rs10069690)G(rs2242652)” haplotypes were associated with an increased risk of esophageal cancer, while the and “C(rs10069690)G(rs2242652)” haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer.
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spelling pubmed-53546772017-04-14 Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer Wu, Yifei Yan, Mengdan Li, Jing Li, Jingjie Chen, Zhengshuai Chen, Peng Li, Bin Chen, Fulin Jin, Tianbo Chen, Chao Oncotarget Research Paper Single nucleotide polymorphisms (SNPs) in TERT may be associated with susceptibility to esophageal cancer. In this study, we analyzed the association between TERT SNPs and risk of esophageal cancer in 386 esophageal cancer patients and 495 healthy subjects from the Xi’an area of China. Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. Additionally, after adjusting for age and gender, the “T(rs10069690)A(rs2242652)”, “T(rs10069690)G(rs2242652)” haplotypes were associated with an increased risk of esophageal cancer, while the and “C(rs10069690)G(rs2242652)” haplotype was associated with a decreased risk of esophageal cancer. These findings suggest that TERT polymorphisms may contribute to the development of esophageal cancer. Impact Journals LLC 2017-01-02 /pmc/articles/PMC5354677/ /pubmed/28060765 http://dx.doi.org/10.18632/oncotarget.14451 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Yifei
Yan, Mengdan
Li, Jing
Li, Jingjie
Chen, Zhengshuai
Chen, Peng
Li, Bin
Chen, Fulin
Jin, Tianbo
Chen, Chao
Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
title Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
title_full Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
title_fullStr Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
title_full_unstemmed Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
title_short Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer
title_sort genetic polymorphisms in tert are associated with increased risk of esophageal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354677/
https://www.ncbi.nlm.nih.gov/pubmed/28060765
http://dx.doi.org/10.18632/oncotarget.14451
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