Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma

Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Sha-sha, Cen, Xiao, Liang, Xin-hua, Tang, Ya-ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354689/
https://www.ncbi.nlm.nih.gov/pubmed/27788497
http://dx.doi.org/10.18632/oncotarget.12890
_version_ 1782515364501913600
author Wang, Sha-sha
Cen, Xiao
Liang, Xin-hua
Tang, Ya-ling
author_facet Wang, Sha-sha
Cen, Xiao
Liang, Xin-hua
Tang, Ya-ling
author_sort Wang, Sha-sha
collection PubMed
description Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC.
format Online
Article
Text
id pubmed-5354689
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-53546892017-04-14 Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma Wang, Sha-sha Cen, Xiao Liang, Xin-hua Tang, Ya-ling Oncotarget Review Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, has been showed to be associated with the immunopathogenesis of many diseases. Recent study demonstrated that MIF promoted tumorigenesis and tumor progression and played a critical role in various kinds of human cancer including head and neck squamous cell carcinoma(HNSCC). Hence, in this paper we retrospected the relationship between MIF and angiogenesis, epithelial-mesenchymal transition (EMT), inflammation, immune response, hypoxia microenvironment, and discussed whether it is a promising biomarker for diagnosis and supervisor of HNSCC. Impact Journals LLC 2016-10-25 /pmc/articles/PMC5354689/ /pubmed/27788497 http://dx.doi.org/10.18632/oncotarget.12890 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Wang, Sha-sha
Cen, Xiao
Liang, Xin-hua
Tang, Ya-ling
Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
title Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
title_full Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
title_fullStr Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
title_full_unstemmed Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
title_short Macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
title_sort macrophage migration inhibitory factor: a potential driver and biomarker for head and neck squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354689/
https://www.ncbi.nlm.nih.gov/pubmed/27788497
http://dx.doi.org/10.18632/oncotarget.12890
work_keys_str_mv AT wangshasha macrophagemigrationinhibitoryfactorapotentialdriverandbiomarkerforheadandnecksquamouscellcarcinoma
AT cenxiao macrophagemigrationinhibitoryfactorapotentialdriverandbiomarkerforheadandnecksquamouscellcarcinoma
AT liangxinhua macrophagemigrationinhibitoryfactorapotentialdriverandbiomarkerforheadandnecksquamouscellcarcinoma
AT tangyaling macrophagemigrationinhibitoryfactorapotentialdriverandbiomarkerforheadandnecksquamouscellcarcinoma

Ejemplares similares