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A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?

We aimed to meta-analytically assess the predisposition of hepatitis C virus (HCV) infection to the occurrence and severity of chronic kidney disease (CKD). Two authors independently searched articles and abstracted information. Odds ratio (OR) or hazard ratio (HR) along with 95% confidence interval...

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Autores principales: Li, Min, Wang, Peiyuan, Yang, Chunhua, Jiang, Wenguo, Wei, Xiaodan, Mu, Xinbo, Li, Xuri, Mi, Jia, Tian, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354692/
https://www.ncbi.nlm.nih.gov/pubmed/27793016
http://dx.doi.org/10.18632/oncotarget.12896
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author Li, Min
Wang, Peiyuan
Yang, Chunhua
Jiang, Wenguo
Wei, Xiaodan
Mu, Xinbo
Li, Xuri
Mi, Jia
Tian, Geng
author_facet Li, Min
Wang, Peiyuan
Yang, Chunhua
Jiang, Wenguo
Wei, Xiaodan
Mu, Xinbo
Li, Xuri
Mi, Jia
Tian, Geng
author_sort Li, Min
collection PubMed
description We aimed to meta-analytically assess the predisposition of hepatitis C virus (HCV) infection to the occurrence and severity of chronic kidney disease (CKD). Two authors independently searched articles and abstracted information. Odds ratio (OR) or hazard ratio (HR) along with 95% confidence interval (CI) was converged separately in 12 longitudinal (1,972,044 subjects) and 15 cross-sectional (937,607 subjects) studies. Overall effect estimate was remarkably significant in longitudinal studies (HR, 95% CI, P: 1.45, 1.23-1.71, < 0.001), in contrast to that in cross-sectional studies (OR, 95% CI, P: 1.25, 0.90-1.73, 0.188), with obvious heterogeneity (I(2) > 95%). HCV infection was also associated with an 1.54-fold (95% CI, P: 1.27-1.87, < 0.001) increased risk of having prevalent proteinuria. In longitudinal studies with estimated glomerular filtration rate (eGFR) < 60, < 30 and < 15 ml/min/1.73m(2), the corresponding HR was 1.39 (95% CI, P: 1.14-1.69, 0.001), 1.79 (0.91-3.51, 0.091) and 2.30 (1.26-4.19, 0.007). Further grouping the longitudinal studies by median follow-up time at 5 years revealed that the effect estimate was reinforced in long-term studies (HR, 95% CI, P: 1.86, 1.19-2.89, 0.006; I(2)=98.1%) relative to that in short-term studies (1.21, 1.03-1.43, 0.024; 92.0%). In conclusion, our findings demonstrate the significant risk of experiencing incident CKD after HCV infection, with the lower eGFR and longer HCV exposure time entailing a greater risk.
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spelling pubmed-53546922017-04-14 A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease? Li, Min Wang, Peiyuan Yang, Chunhua Jiang, Wenguo Wei, Xiaodan Mu, Xinbo Li, Xuri Mi, Jia Tian, Geng Oncotarget Review We aimed to meta-analytically assess the predisposition of hepatitis C virus (HCV) infection to the occurrence and severity of chronic kidney disease (CKD). Two authors independently searched articles and abstracted information. Odds ratio (OR) or hazard ratio (HR) along with 95% confidence interval (CI) was converged separately in 12 longitudinal (1,972,044 subjects) and 15 cross-sectional (937,607 subjects) studies. Overall effect estimate was remarkably significant in longitudinal studies (HR, 95% CI, P: 1.45, 1.23-1.71, < 0.001), in contrast to that in cross-sectional studies (OR, 95% CI, P: 1.25, 0.90-1.73, 0.188), with obvious heterogeneity (I(2) > 95%). HCV infection was also associated with an 1.54-fold (95% CI, P: 1.27-1.87, < 0.001) increased risk of having prevalent proteinuria. In longitudinal studies with estimated glomerular filtration rate (eGFR) < 60, < 30 and < 15 ml/min/1.73m(2), the corresponding HR was 1.39 (95% CI, P: 1.14-1.69, 0.001), 1.79 (0.91-3.51, 0.091) and 2.30 (1.26-4.19, 0.007). Further grouping the longitudinal studies by median follow-up time at 5 years revealed that the effect estimate was reinforced in long-term studies (HR, 95% CI, P: 1.86, 1.19-2.89, 0.006; I(2)=98.1%) relative to that in short-term studies (1.21, 1.03-1.43, 0.024; 92.0%). In conclusion, our findings demonstrate the significant risk of experiencing incident CKD after HCV infection, with the lower eGFR and longer HCV exposure time entailing a greater risk. Impact Journals LLC 2016-10-25 /pmc/articles/PMC5354692/ /pubmed/27793016 http://dx.doi.org/10.18632/oncotarget.12896 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Li, Min
Wang, Peiyuan
Yang, Chunhua
Jiang, Wenguo
Wei, Xiaodan
Mu, Xinbo
Li, Xuri
Mi, Jia
Tian, Geng
A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?
title A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?
title_full A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?
title_fullStr A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?
title_full_unstemmed A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?
title_short A systematic review and meta-analysis: Does hepatitis C virus infection predispose to the development of chronic kidney disease?
title_sort systematic review and meta-analysis: does hepatitis c virus infection predispose to the development of chronic kidney disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354692/
https://www.ncbi.nlm.nih.gov/pubmed/27793016
http://dx.doi.org/10.18632/oncotarget.12896
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