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FDA-approved medications that impair human spermatogenesis
We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official websit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354694/ https://www.ncbi.nlm.nih.gov/pubmed/27801671 http://dx.doi.org/10.18632/oncotarget.12956 |
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author | Ding, Jiayi Shang, Xuejun Zhang, Zhanhu Jing, Hua Shao, Jun Fei, Qianqian Rayburn, Elizabeth R. Li, Haibo |
author_facet | Ding, Jiayi Shang, Xuejun Zhang, Zhanhu Jing, Hua Shao, Jun Fei, Qianqian Rayburn, Elizabeth R. Li, Haibo |
author_sort | Ding, Jiayi |
collection | PubMed |
description | We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official website for FDA-approved drug labels. Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. Overall, there were a total of 65 labels for drugs of various classes that showed that they have the potential to affect human sperm production and maturation. We identified several drugs indicated to be spermatotoxic in the drug labels that were not reported in the peer-reviewed literature. However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. Therefore, additional work is needed at both the basic research level and during clinical trials and post-marketing surveillance to fill the gaps in the current knowledge. The present findings will be of interest to physicians and pharmacists, researchers, and those involved in drug development and health care policy. |
format | Online Article Text |
id | pubmed-5354694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53546942017-04-14 FDA-approved medications that impair human spermatogenesis Ding, Jiayi Shang, Xuejun Zhang, Zhanhu Jing, Hua Shao, Jun Fei, Qianqian Rayburn, Elizabeth R. Li, Haibo Oncotarget Review We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official website for FDA-approved drug labels. Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. Overall, there were a total of 65 labels for drugs of various classes that showed that they have the potential to affect human sperm production and maturation. We identified several drugs indicated to be spermatotoxic in the drug labels that were not reported in the peer-reviewed literature. However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. Therefore, additional work is needed at both the basic research level and during clinical trials and post-marketing surveillance to fill the gaps in the current knowledge. The present findings will be of interest to physicians and pharmacists, researchers, and those involved in drug development and health care policy. Impact Journals LLC 2016-10-27 /pmc/articles/PMC5354694/ /pubmed/27801671 http://dx.doi.org/10.18632/oncotarget.12956 Text en Copyright: © 2017 Ding et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Ding, Jiayi Shang, Xuejun Zhang, Zhanhu Jing, Hua Shao, Jun Fei, Qianqian Rayburn, Elizabeth R. Li, Haibo FDA-approved medications that impair human spermatogenesis |
title | FDA-approved medications that impair human spermatogenesis |
title_full | FDA-approved medications that impair human spermatogenesis |
title_fullStr | FDA-approved medications that impair human spermatogenesis |
title_full_unstemmed | FDA-approved medications that impair human spermatogenesis |
title_short | FDA-approved medications that impair human spermatogenesis |
title_sort | fda-approved medications that impair human spermatogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354694/ https://www.ncbi.nlm.nih.gov/pubmed/27801671 http://dx.doi.org/10.18632/oncotarget.12956 |
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