Metformin: a metabolic modulator

Recent findings have shed new light on the mechanisms of action through which biguanides exert their anti-aging and cytostatic effects in Caenorhabditis elegans and human cell lines. The drop in energy charge resulting from the metformin mediated inhibition of mitochondrial activity affects the func...

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Detalles Bibliográficos
Autores principales: Pietrocola, Federico, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Perspective: Autophagy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354711/
https://www.ncbi.nlm.nih.gov/pubmed/28122334
http://dx.doi.org/10.18632/oncotarget.14794
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author Pietrocola, Federico
Kroemer, Guido
author_facet Pietrocola, Federico
Kroemer, Guido
author_sort Pietrocola, Federico
collection PubMed
description Recent findings have shed new light on the mechanisms of action through which biguanides exert their anti-aging and cytostatic effects in Caenorhabditis elegans and human cell lines. The drop in energy charge resulting from the metformin mediated inhibition of mitochondrial activity affects the function of the nuclear pore complex, blocks mTOR signaling and enhances the expression of ACAD10. Whether the inhibition of this pathway is truly responsible for the anti-diabetic and cancer effects of the drug in mammals remains to be established.
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spelling pubmed-53547112017-04-14 Metformin: a metabolic modulator Pietrocola, Federico Kroemer, Guido Oncotarget Research Perspective: Autophagy Recent findings have shed new light on the mechanisms of action through which biguanides exert their anti-aging and cytostatic effects in Caenorhabditis elegans and human cell lines. The drop in energy charge resulting from the metformin mediated inhibition of mitochondrial activity affects the function of the nuclear pore complex, blocks mTOR signaling and enhances the expression of ACAD10. Whether the inhibition of this pathway is truly responsible for the anti-diabetic and cancer effects of the drug in mammals remains to be established. Impact Journals LLC 2017-01-22 /pmc/articles/PMC5354711/ /pubmed/28122334 http://dx.doi.org/10.18632/oncotarget.14794 Text en Copyright: © 2017 Pietrocola et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective: Autophagy
Pietrocola, Federico
Kroemer, Guido
Metformin: a metabolic modulator
title Metformin: a metabolic modulator
title_full Metformin: a metabolic modulator
title_fullStr Metformin: a metabolic modulator
title_full_unstemmed Metformin: a metabolic modulator
title_short Metformin: a metabolic modulator
title_sort metformin: a metabolic modulator
topic Research Perspective: Autophagy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354711/
https://www.ncbi.nlm.nih.gov/pubmed/28122334
http://dx.doi.org/10.18632/oncotarget.14794
work_keys_str_mv AT pietrocolafederico metforminametabolicmodulator
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