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Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes
Recombinant immunotoxins (RITs) are antibody-based therapeutics that carry a toxin payload. The RG7787 RIT targets the cancer antigen mesothelin to deliver a recombinantly-engineered, reduced immunogenicity variant of Pseudomonas exotoxin A (PE) to the cytosol where it inhibits protein synthesis. He...
Autores principales: | Kolyvas, Emily, Rudloff, Michael, Poruchynsky, Marianne, Landsman, Rebekah, Hollevoet, Kevin, Venzon, David, Alewine, Christine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354724/ https://www.ncbi.nlm.nih.gov/pubmed/27999204 http://dx.doi.org/10.18632/oncotarget.13984 |
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