Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells

Dysregulation of inhibitor of apoptosis (IAP) proteins (IAPs) in hepatocellular carcinoma (HCC) is often associated with poor prognosis. Here we showed that AT406, an IAP antagonist, was cytotoxic and pro-apoptotic to both established (HepG2, SMMC-7721 lines) and primary HCC cells. Activation of mTO...

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Detalles Bibliográficos
Autores principales: Zhen, Mao-Chuan, Wang, Fu-Qiang, Wu, Shao-Feng, Zhao, Yi-Lin, Liu, Ping-Guo, Yin, Zhen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354745/
https://www.ncbi.nlm.nih.gov/pubmed/28036295
http://dx.doi.org/10.18632/oncotarget.14326

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