TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using the TALEN gene-edit...

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Detalles Bibliográficos
Autores principales: Dufour, Florent, Rattier, Thibault, Constantinescu, Andrei Alexandru, Zischler, Luciana, Morlé, Aymeric, Mabrouk, Hazem Ben, Humblin, Etienne, Jacquemin, Guillaume, Szegezdi, Eva, Delacote, Fabien, Marrakchi, Naziha, Guichard, Gilles, Pellat-Deceunynck, Catherine, Vacher, Pierre, Legembre, Patrick, Garrido, Carmen, Micheau, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354785/
https://www.ncbi.nlm.nih.gov/pubmed/28039489
http://dx.doi.org/10.18632/oncotarget.14285

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