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Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis
Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell grow...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354803/ https://www.ncbi.nlm.nih.gov/pubmed/27965466 http://dx.doi.org/10.18632/oncotarget.13904 |
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author | Ivanov, Alexander V. Valuev-Elliston, Vladimir T. Tyurina, Daria A. Ivanova, Olga N. Kochetkov, Sergey N. Bartosch, Birke Isaguliants, Maria G. |
author_facet | Ivanov, Alexander V. Valuev-Elliston, Vladimir T. Tyurina, Daria A. Ivanova, Olga N. Kochetkov, Sergey N. Bartosch, Birke Isaguliants, Maria G. |
author_sort | Ivanov, Alexander V. |
collection | PubMed |
description | Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review. |
format | Online Article Text |
id | pubmed-5354803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53548032017-04-24 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis Ivanov, Alexander V. Valuev-Elliston, Vladimir T. Tyurina, Daria A. Ivanova, Olga N. Kochetkov, Sergey N. Bartosch, Birke Isaguliants, Maria G. Oncotarget Research Paper Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review. Impact Journals LLC 2016-12-11 /pmc/articles/PMC5354803/ /pubmed/27965466 http://dx.doi.org/10.18632/oncotarget.13904 Text en Copyright: © 2017 Ivanov et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ivanov, Alexander V. Valuev-Elliston, Vladimir T. Tyurina, Daria A. Ivanova, Olga N. Kochetkov, Sergey N. Bartosch, Birke Isaguliants, Maria G. Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis |
title | Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis |
title_full | Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis |
title_fullStr | Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis |
title_full_unstemmed | Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis |
title_short | Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis |
title_sort | oxidative stress, a trigger of hepatitis c and b virus-induced liver carcinogenesis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354803/ https://www.ncbi.nlm.nih.gov/pubmed/27965466 http://dx.doi.org/10.18632/oncotarget.13904 |
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