Cargando…

Isochaihulactone-induced DDIT3 causes ER stress-PERK independent apoptosis in glioblastoma multiforme cells

The endoplasmic reticulum (ER) is a major site of cellular homeostasis regulation. Under the ER stress condition, Glioblastoma multiform (GBM) cells activate the unfolded protein response. In this study, we discovered isochaihulactone, a natural compound extracted from the Chinese traditional herb N...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsai, Sheng-Feng, Tao, Michael, Ho, Li-Ing, Chiou, Tzyy-Wen, Lin, Shinn-Zong, Su, Hong-Lin, Harn, Horng-Jyh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354812/ https://www.ncbi.nlm.nih.gov/pubmed/27852055 http://dx.doi.org/10.18632/oncotarget.13266

Ejemplares similares

Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells
por: Chiu, Sheng-Chun, et al.
Publicado: (2011)

Chinese herbs and acupuncture to improve cognitive function in Alzheimer's disease
por: WuLi, Wei, et al.
Publicado: (2021)

n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
por: Yen, Ssu-Yin, et al.
Publicado: (2017)

Predictors of Response to Autologous Dendritic Cell Therapy in Glioblastoma Multiforme
por: Jan, Chia-Ing, et al.
Publicado: (2018)

Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
por: Lee, Jui-Hao, et al.
Publicado: (2018)

Effect of Cinnamomum osmophloeum Kanehira Leaf Aqueous Extract on Dermal Papilla Cell Proliferation and Hair Growth
por: Wen, Tung-Chou, et al.
Publicado: (2018)

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
por: Lee, Jui-Hao, et al.
Publicado: (2021)

Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
por: Chuang, Hong-Meng, et al.
Publicado: (2018)

The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
por: Chuang, Hong-Meng, et al.
Publicado: (2016)

Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment
por: Liu, Ching-Ann, et al.
Publicado: (2018)

Induced Pluripotent Stem Cells: A Powerful Neurodegenerative Disease Modeling Tool for Mechanism Study and Drug Discovery
por: Chang, Chia-Yu, et al.
Publicado: (2018)

Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling
por: Ting, Hsiao-Chien, et al.
Publicado: (2022)

Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer’s Disease
por: Wuli, Wei, et al.
Publicado: (2020)

Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling
por: Ou, Jie-Ping, et al.
Publicado: (2012)

The Role of Biomaterials in Implantation for Central Nervous System Injury
por: Chen, Yu-Shuan, et al.
Publicado: (2018)

Food Supplement 20070721-GX May Increase CD34(+) Stem Cells and Telomerase Activity
por: Lin, Po-Cheng, et al.
Publicado: (2012)

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
por: Chang, Chia-Yu, et al.
Publicado: (2020)

Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats
por: Lee, Tsung-Ming, et al.
Publicado: (2019)

Host pre‐conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome
por: Lee, Tsung‐Ming, et al.
Publicado: (2020)

Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages
por: Chang, Chia-Yu, et al.
Publicado: (2021)

Exosomes in clinical trial and their production in compliance with good manufacturing practice
por: Chen, Yu-Shuan, et al.
Publicado: (2019)

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction
por: LEE, Tsung-Ming, et al.
Publicado: (2021)

Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons
por: Ting, Hsiao-Chien, et al.
Publicado: (2021)

Deep Brain Stimulation for Amelioration of Cognitive Impairment in Neurological Disorders: Neurogenesis and Circuit Reanimation
por: Tsai, Sheng-Tzung, et al.
Publicado: (2018)

Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado–Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies
por: Chen, Yu-Shuan, et al.
Publicado: (2020)

Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
por: Hsieh, Jeanne, et al.
Publicado: (2017)

Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA
por: Lin, Cheng Yung, et al.
Publicado: (2019)

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model
por: Yang, Hsin-Han, et al.
Publicado: (2020)

Pancreatic Adenocarcinoma Therapeutics Targeting RTK and TGF Beta Receptor
por: Yang, Hsin-Han, et al.
Publicado: (2021)

The Role of Gene Editing in Neurodegenerative Diseases
por: Fan, Hueng-Chuen, et al.
Publicado: (2018)

Current Immunotherapies for Glioblastoma Multiforme
por: Huang, Boyuan, et al.
Publicado: (2021)

Integration of PEG 400 into a self-nanoemulsifying drug delivery system improves drug loading capacity and nasal mucosa permeability and prolongs the survival of rats with malignant brain tumors
por: Chen, Yu-Shuan, et al.
Publicado: (2019)

Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats
por: Wu, Shih-Fang, et al.
Publicado: (2022)

PERK-mediated Autophagy in Osteosarcoma Cells Resists ER Stress-induced Cell Apoptosis
por: Ji, Guang-rong, et al.
Publicado: (2015)

Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
por: Chang, Yu-Hsun, et al.
Publicado: (2018)

Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance
por: Liu, Ching-Ann, et al.
Publicado: (2022)

Induction of Mitosis Delay and Apoptosis by CDDO-TFEA in Glioblastoma Multiforme
por: Tsai, Tai-Hsin, et al.
Publicado: (2021)

Glioblastoma Multiforme
por: Sheehan, Jonas M., et al.
Publicado: (2012)

Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma
por: Fan, Hueng-Chuen, et al.
Publicado: (2019)

ER stress PERKs up an miRNA
por: Short, Ben
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_e763aoboc186gv94t6ma2838cu