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HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study

Long term outcome of ablation-assisted hepatic resection is unclear for hepatocellular carcinoma (HCC) patients. This study was scheduled to compare the outcome of Habib 4X ablation assisted resection (Habib group) with clamp-crush resection (CC group) for HCC. In this study, we retrospectively enro...

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Autores principales: Qiu, Jiliang, Lu, Weiqun, Yu, Nanrong, Yang, Guohua, Li, Yi, Huang, Zhiliang, Li, Jianchang, Li, Kefei, Xu, Houwei, Chen, Shicai, Zeng, Xiang, Liu, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354825/
https://www.ncbi.nlm.nih.gov/pubmed/27965468
http://dx.doi.org/10.18632/oncotarget.13906
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author Qiu, Jiliang
Lu, Weiqun
Yu, Nanrong
Yang, Guohua
Li, Yi
Huang, Zhiliang
Li, Jianchang
Li, Kefei
Xu, Houwei
Chen, Shicai
Zeng, Xiang
Liu, Haiying
author_facet Qiu, Jiliang
Lu, Weiqun
Yu, Nanrong
Yang, Guohua
Li, Yi
Huang, Zhiliang
Li, Jianchang
Li, Kefei
Xu, Houwei
Chen, Shicai
Zeng, Xiang
Liu, Haiying
author_sort Qiu, Jiliang
collection PubMed
description Long term outcome of ablation-assisted hepatic resection is unclear for hepatocellular carcinoma (HCC) patients. This study was scheduled to compare the outcome of Habib 4X ablation assisted resection (Habib group) with clamp-crush resection (CC group) for HCC. In this study, we retrospectively enrolled 81 patients from the Habib group and 103 patients from the CC group. Oncologic outcomes were analyzed using a propensity score matching (PSM) method. Compared with the CC group, the Habib group had higher levels of γ-glutamyltransferase (P=0.044) and albumin (P=0.001), larger tumor sizes (P=0.007), shorter operation times (P=0.001), less blood loss (P=0.005), and less blood transfusions (P=0.038). There were no significant differences in complications (P=0.310), recurrence-free survival rates (RFS, P=0.112), or overall survival rates (OS, P=0.203) between the two groups. For the 67 patient pairs selected from the PSM analysis, the Habib group had better RFS and OS (P=0.033 and P=0.014, respectively). A Cox proportional hazards analysis revealed that Habib-assisted resection was an independent factor for RFS and OS (P=0.008 and P=0.016, respectively). Furthermore, for the 42 patients with central and large tumors, the Habib group had better RFS and OS than the CC group (P=0.035 and P=0.038, respectively). However, the differences of RFS and OS (P=0.117 and P=0.126, respectively) were not significant among 92 patients with peripheral or small tumors. Hence, Habib(TM) 4X-assisted resection is safe and provides better survival for HCC patients, particularly those with central and large tumors.
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spelling pubmed-53548252017-04-24 HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study Qiu, Jiliang Lu, Weiqun Yu, Nanrong Yang, Guohua Li, Yi Huang, Zhiliang Li, Jianchang Li, Kefei Xu, Houwei Chen, Shicai Zeng, Xiang Liu, Haiying Oncotarget Research Paper Long term outcome of ablation-assisted hepatic resection is unclear for hepatocellular carcinoma (HCC) patients. This study was scheduled to compare the outcome of Habib 4X ablation assisted resection (Habib group) with clamp-crush resection (CC group) for HCC. In this study, we retrospectively enrolled 81 patients from the Habib group and 103 patients from the CC group. Oncologic outcomes were analyzed using a propensity score matching (PSM) method. Compared with the CC group, the Habib group had higher levels of γ-glutamyltransferase (P=0.044) and albumin (P=0.001), larger tumor sizes (P=0.007), shorter operation times (P=0.001), less blood loss (P=0.005), and less blood transfusions (P=0.038). There were no significant differences in complications (P=0.310), recurrence-free survival rates (RFS, P=0.112), or overall survival rates (OS, P=0.203) between the two groups. For the 67 patient pairs selected from the PSM analysis, the Habib group had better RFS and OS (P=0.033 and P=0.014, respectively). A Cox proportional hazards analysis revealed that Habib-assisted resection was an independent factor for RFS and OS (P=0.008 and P=0.016, respectively). Furthermore, for the 42 patients with central and large tumors, the Habib group had better RFS and OS than the CC group (P=0.035 and P=0.038, respectively). However, the differences of RFS and OS (P=0.117 and P=0.126, respectively) were not significant among 92 patients with peripheral or small tumors. Hence, Habib(TM) 4X-assisted resection is safe and provides better survival for HCC patients, particularly those with central and large tumors. Impact Journals LLC 2016-11-21 /pmc/articles/PMC5354825/ /pubmed/27965468 http://dx.doi.org/10.18632/oncotarget.13906 Text en Copyright: © 2017 Qiu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Qiu, Jiliang
Lu, Weiqun
Yu, Nanrong
Yang, Guohua
Li, Yi
Huang, Zhiliang
Li, Jianchang
Li, Kefei
Xu, Houwei
Chen, Shicai
Zeng, Xiang
Liu, Haiying
HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
title HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
title_full HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
title_fullStr HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
title_full_unstemmed HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
title_short HabibTM 4X-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
title_sort habibtm 4x-assisted resection versus clamp-crush resection for hepatocellular carcinoma: a propensity-matching study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354825/
https://www.ncbi.nlm.nih.gov/pubmed/27965468
http://dx.doi.org/10.18632/oncotarget.13906
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