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Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354840/ https://www.ncbi.nlm.nih.gov/pubmed/27966457 http://dx.doi.org/10.18632/oncotarget.13876 |
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author | Lien, Shin-Yu A. Young, Lufei Gau, Bih-Shya Shiao, S. Pamela K. |
author_facet | Lien, Shin-Yu A. Young, Lufei Gau, Bih-Shya Shiao, S. Pamela K. |
author_sort | Lien, Shin-Yu A. |
collection | PubMed |
description | The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia. |
format | Online Article Text |
id | pubmed-5354840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53548402017-04-24 Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations Lien, Shin-Yu A. Young, Lufei Gau, Bih-Shya Shiao, S. Pamela K. Oncotarget Research Paper The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia. Impact Journals LLC 2016-12-10 /pmc/articles/PMC5354840/ /pubmed/27966457 http://dx.doi.org/10.18632/oncotarget.13876 Text en Copyright: © 2017 Lien et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lien, Shin-Yu A. Young, Lufei Gau, Bih-Shya Shiao, S. Pamela K. Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
title | Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
title_full | Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
title_fullStr | Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
title_full_unstemmed | Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
title_short | Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
title_sort | meta-prediction of mthfr gene polymorphism-mutations, air pollution, and risks of leukemia among world populations |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354840/ https://www.ncbi.nlm.nih.gov/pubmed/27966457 http://dx.doi.org/10.18632/oncotarget.13876 |
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