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Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations

The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine th...

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Autores principales: Lien, Shin-Yu A., Young, Lufei, Gau, Bih-Shya, Shiao, S. Pamela K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354840/
https://www.ncbi.nlm.nih.gov/pubmed/27966457
http://dx.doi.org/10.18632/oncotarget.13876
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author Lien, Shin-Yu A.
Young, Lufei
Gau, Bih-Shya
Shiao, S. Pamela K.
author_facet Lien, Shin-Yu A.
Young, Lufei
Gau, Bih-Shya
Shiao, S. Pamela K.
author_sort Lien, Shin-Yu A.
collection PubMed
description The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia.
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spelling pubmed-53548402017-04-24 Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations Lien, Shin-Yu A. Young, Lufei Gau, Bih-Shya Shiao, S. Pamela K. Oncotarget Research Paper The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (including air pollution), MTHFR polymorphisms, and the risks of developing leukemia. We completed a comprehensive search of 6 databases to find 54 studies (10,033 leukemia cases and 15,835 controls) for MTHFR 677, and 43 studies (8,868 cases and 14,301 controls) for MTHFR 1298, published from 1999 to 2014. The results revealed that, in European populations; childhood populations; children from Europe, East Asia, and America; and children with acute lymphocytic leukemia (ALL), MTHFR 677 polymorphisms (both TT and CT types together and individually) are protective, while CC wildtype was leukemogenic. In addition, MTHFR 1298 polymorphisms were protective against ALL and acute myeloid leukemia in European children, and in chronic myeloid leukemia in all adults worldwide and American adults. Air pollution played a role in the increased polymorphisms of MTHFR 677 genotypes in childhood leukemia. Impact Journals LLC 2016-12-10 /pmc/articles/PMC5354840/ /pubmed/27966457 http://dx.doi.org/10.18632/oncotarget.13876 Text en Copyright: © 2017 Lien et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lien, Shin-Yu A.
Young, Lufei
Gau, Bih-Shya
Shiao, S. Pamela K.
Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
title Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
title_full Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
title_fullStr Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
title_full_unstemmed Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
title_short Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
title_sort meta-prediction of mthfr gene polymorphism-mutations, air pollution, and risks of leukemia among world populations
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354840/
https://www.ncbi.nlm.nih.gov/pubmed/27966457
http://dx.doi.org/10.18632/oncotarget.13876
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