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High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes
Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological knowledge on signal transduction. The method recodes individual gene expression...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354899/ https://www.ncbi.nlm.nih.gov/pubmed/28042959 http://dx.doi.org/10.18632/oncotarget.14107 |