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Protective effects of oxymatrine against arsenic trioxide-induced liver injury

Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As(2)O(3))-induced liver injury has not been reported. In the present study, we in...

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Autores principales: Li, Li, Liu, Qinghai, Fan, Long, Xiao, Wei, Zhao, Lei, Wang, Yu, Ye, Weiguang, Lan, Fei, Jia, Bin, Feng, Hua, Zhou, Changman, Yue, Xiuqin, Xing, Guogang, Wang, Tianlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355055/
https://www.ncbi.nlm.nih.gov/pubmed/27713174
http://dx.doi.org/10.18632/oncotarget.12478
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author Li, Li
Liu, Qinghai
Fan, Long
Xiao, Wei
Zhao, Lei
Wang, Yu
Ye, Weiguang
Lan, Fei
Jia, Bin
Feng, Hua
Zhou, Changman
Yue, Xiuqin
Xing, Guogang
Wang, Tianlong
author_facet Li, Li
Liu, Qinghai
Fan, Long
Xiao, Wei
Zhao, Lei
Wang, Yu
Ye, Weiguang
Lan, Fei
Jia, Bin
Feng, Hua
Zhou, Changman
Yue, Xiuqin
Xing, Guogang
Wang, Tianlong
author_sort Li, Li
collection PubMed
description Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As(2)O(3))-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As(2)O(3)-induced liver injury in rats. Male Wistar rats were administrated 3mg/kg As(2)O(3) intravenous injection on alternate days for 4 days. Oxymatrine was given 1 h before As(2)O(3) treatment. The results showed that oxymatrine inhibited As(2)O(3)-induced hepatic pathological damage, liver ROS level and MDA level in a dose-dependent manner. As(2)O(3) decreased the antioxidant enzymes SOD, GPX, and CAT activity and the decrease was inhibited by treatment of oxymatrine. Furthermore, oxymatrine attenuated the retention of arsenic in liver tissues and improved the expression of Nrf2 and HO-1. In conclusion, our results suggested that oxymatrine protected against As(2)O(3)-induced oxidative damage by activating Nrf2/HO-1 signaling pathway.
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spelling pubmed-53550552017-04-15 Protective effects of oxymatrine against arsenic trioxide-induced liver injury Li, Li Liu, Qinghai Fan, Long Xiao, Wei Zhao, Lei Wang, Yu Ye, Weiguang Lan, Fei Jia, Bin Feng, Hua Zhou, Changman Yue, Xiuqin Xing, Guogang Wang, Tianlong Oncotarget Research Paper Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As(2)O(3))-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As(2)O(3)-induced liver injury in rats. Male Wistar rats were administrated 3mg/kg As(2)O(3) intravenous injection on alternate days for 4 days. Oxymatrine was given 1 h before As(2)O(3) treatment. The results showed that oxymatrine inhibited As(2)O(3)-induced hepatic pathological damage, liver ROS level and MDA level in a dose-dependent manner. As(2)O(3) decreased the antioxidant enzymes SOD, GPX, and CAT activity and the decrease was inhibited by treatment of oxymatrine. Furthermore, oxymatrine attenuated the retention of arsenic in liver tissues and improved the expression of Nrf2 and HO-1. In conclusion, our results suggested that oxymatrine protected against As(2)O(3)-induced oxidative damage by activating Nrf2/HO-1 signaling pathway. Impact Journals LLC 2016-10-05 /pmc/articles/PMC5355055/ /pubmed/27713174 http://dx.doi.org/10.18632/oncotarget.12478 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Li
Liu, Qinghai
Fan, Long
Xiao, Wei
Zhao, Lei
Wang, Yu
Ye, Weiguang
Lan, Fei
Jia, Bin
Feng, Hua
Zhou, Changman
Yue, Xiuqin
Xing, Guogang
Wang, Tianlong
Protective effects of oxymatrine against arsenic trioxide-induced liver injury
title Protective effects of oxymatrine against arsenic trioxide-induced liver injury
title_full Protective effects of oxymatrine against arsenic trioxide-induced liver injury
title_fullStr Protective effects of oxymatrine against arsenic trioxide-induced liver injury
title_full_unstemmed Protective effects of oxymatrine against arsenic trioxide-induced liver injury
title_short Protective effects of oxymatrine against arsenic trioxide-induced liver injury
title_sort protective effects of oxymatrine against arsenic trioxide-induced liver injury
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355055/
https://www.ncbi.nlm.nih.gov/pubmed/27713174
http://dx.doi.org/10.18632/oncotarget.12478
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