A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

A prior screening programme carried out using MTT assay by our group identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cispl...

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Detalles Bibliográficos
Autores principales: Dai, Xiaoyun, Wang, Lingzhi, Deivasigamni, Amudha, Looi, Chung Yeng, Karthikeyan, Chandrabose, Trivedi, Piyush, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Arfuso, Frank, Dharmarajan, Arunasalam, Goh, Boon Cher, Hui, Kam Man, Kumar, Alan Prem, Mustafa, Mohd Rais, Sethi, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355059/
https://www.ncbi.nlm.nih.gov/pubmed/28086233
http://dx.doi.org/10.18632/oncotarget.14606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355059/
https://www.ncbi.nlm.nih.gov/pubmed/28086233
http://dx.doi.org/10.18632/oncotarget.14606

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