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High-throughput proteome analysis reveals targeted TRPM8 degradation in prostate cancer

The Ca(2+)-permeable ion channel TRPM8 is a hallmark of the prostate epithelium. We recently discovered that TRPM8 is an ionotropic testosterone receptor. This finding suggested that testosterone-induced TRPM8 activity regulates Ca(2+) homeostasis in the prostate epithelium. Since androgens are sign...

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Detalles Bibliográficos
Autores principales:	Asuthkar, Swapna, Demirkhanyan, Lusine, Mueting, Samuel Robert, Cohen, Alejandro, Zakharian, Eleonora
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355063/ https://www.ncbi.nlm.nih.gov/pubmed/28039451 http://dx.doi.org/10.18632/oncotarget.14178

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