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Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females
Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and femal...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355085/ https://www.ncbi.nlm.nih.gov/pubmed/28061459 http://dx.doi.org/10.18632/oncotarget.14486 |
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author | Sun, Yu-Xiao Gao, Chuan-Yu Lu, Yang Fu, Xin Jia, Jun-Ge Zhao, Yu-Jie Li, Lian-Dong Dui, Hong-zhi Zhang, Xing-Yu Li, Zhi-Ying Lei, Lei Zhang, Wei-Feng Yuan, Yi-Qiang |
author_facet | Sun, Yu-Xiao Gao, Chuan-Yu Lu, Yang Fu, Xin Jia, Jun-Ge Zhao, Yu-Jie Li, Lian-Dong Dui, Hong-zhi Zhang, Xing-Yu Li, Zhi-Ying Lei, Lei Zhang, Wei-Feng Yuan, Yi-Qiang |
author_sort | Sun, Yu-Xiao |
collection | PubMed |
description | Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and female subgroups. Five PPAP2B polymorphisms (SNPs) were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age and gender. Allelic model analysis revealed that for PPAP2B rs1759752, allele frequency distributions differed between cases and controls in the male subgroup (p = 0.015, OR: 1.401, 95%CI: 1.066–1.481). Genetic model analysis revealed that in the male subgroup, rs1759752 was associated with increased CHD risk in the dominant model (p = 0.035) and overdominant model (p = 0.045). In the female subgroup, rs12566304 was associated with a decreased CHD risk in the codominant model (p = 0.038) and overdominant model (p = 0.031). Additionally, the “GC” haplotypes of rs1759752 and rs1930760 were protective against CHD in males. These observations shed new light on gender-related differences in the association between PPAP2B gene polymorphisms and CHD susceptibility in the Chinese Han population. |
format | Online Article Text |
id | pubmed-5355085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53550852017-04-15 Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females Sun, Yu-Xiao Gao, Chuan-Yu Lu, Yang Fu, Xin Jia, Jun-Ge Zhao, Yu-Jie Li, Lian-Dong Dui, Hong-zhi Zhang, Xing-Yu Li, Zhi-Ying Lei, Lei Zhang, Wei-Feng Yuan, Yi-Qiang Oncotarget Research Paper Little is known about gender-related differences in the association between PPAP2B single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) in Chinese Han males and females. We therefore conducted a case-control study with 456 cases and 685 healthy controls divided into male and female subgroups. Five PPAP2B polymorphisms (SNPs) were selected and genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age and gender. Allelic model analysis revealed that for PPAP2B rs1759752, allele frequency distributions differed between cases and controls in the male subgroup (p = 0.015, OR: 1.401, 95%CI: 1.066–1.481). Genetic model analysis revealed that in the male subgroup, rs1759752 was associated with increased CHD risk in the dominant model (p = 0.035) and overdominant model (p = 0.045). In the female subgroup, rs12566304 was associated with a decreased CHD risk in the codominant model (p = 0.038) and overdominant model (p = 0.031). Additionally, the “GC” haplotypes of rs1759752 and rs1930760 were protective against CHD in males. These observations shed new light on gender-related differences in the association between PPAP2B gene polymorphisms and CHD susceptibility in the Chinese Han population. Impact Journals LLC 2017-01-04 /pmc/articles/PMC5355085/ /pubmed/28061459 http://dx.doi.org/10.18632/oncotarget.14486 Text en Copyright: © 2017 Sun et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Sun, Yu-Xiao Gao, Chuan-Yu Lu, Yang Fu, Xin Jia, Jun-Ge Zhao, Yu-Jie Li, Lian-Dong Dui, Hong-zhi Zhang, Xing-Yu Li, Zhi-Ying Lei, Lei Zhang, Wei-Feng Yuan, Yi-Qiang Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females |
title | Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females |
title_full | Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females |
title_fullStr | Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females |
title_full_unstemmed | Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females |
title_short | Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females |
title_sort | association between ppap2b gene polymorphisms and coronary heart disease susceptibility in chinese han males and females |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355085/ https://www.ncbi.nlm.nih.gov/pubmed/28061459 http://dx.doi.org/10.18632/oncotarget.14486 |
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