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Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis

BACKGROUND AND OBJECTIVE: The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker. METHODS: We systemati...

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Autores principales: Chen, Xiu, Lu, Peng, Zhou, Siying, Zhang, Lei, Zhao, Jian-hua, Tang, Jin-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355089/
https://www.ncbi.nlm.nih.gov/pubmed/28086215
http://dx.doi.org/10.18632/oncotarget.14570
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author Chen, Xiu
Lu, Peng
Zhou, Siying
Zhang, Lei
Zhao, Jian-hua
Tang, Jin-hai
author_facet Chen, Xiu
Lu, Peng
Zhou, Siying
Zhang, Lei
Zhao, Jian-hua
Tang, Jin-hai
author_sort Chen, Xiu
collection PubMed
description BACKGROUND AND OBJECTIVE: The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker. METHODS: We systematically searched the PubMed, EMbase and Medline databases for relevant published studies that were consistent with the eligible criteria up to January 2016, and calculated pooled estimated hazard ratios of GLUT-1 and -3′s expressions in different cancer types and ethnic populations. Random-effects models were used to assess estimates from studies with significant heterogeneities. RESULTS: Overall, 12 studies concerning GLUT 1 and 2 studies concerning GLUT 3, which involved 2008 participants when combined, were included in this analysis. We found that overexpression of GLUTs were significantly correlated to poorer survival rates (HR=1.63, 95%CI=1.09-2.44 and HR=1.89, 95%CI=1.28-2.81). In the subgroup analysis, the GLUT 1 up-regulation was correlated with negative overall survival in pancreatic cancer and gastric cancer and with better overall survival in colorectal cancer. In addition, overexpression of GLUT 1 was associated with a poorer prognosis in the Asian population, while no significance was found in the non-Asian subgroup. However, limitations do exist, which could be handled better. CONCLUSIONS: A combination of GLUTs 1 and 3 might help predict malignancy of cancers and direct effective cancer therapy.
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spelling pubmed-53550892017-04-15 Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis Chen, Xiu Lu, Peng Zhou, Siying Zhang, Lei Zhao, Jian-hua Tang, Jin-hai Oncotarget Research Paper BACKGROUND AND OBJECTIVE: The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker. METHODS: We systematically searched the PubMed, EMbase and Medline databases for relevant published studies that were consistent with the eligible criteria up to January 2016, and calculated pooled estimated hazard ratios of GLUT-1 and -3′s expressions in different cancer types and ethnic populations. Random-effects models were used to assess estimates from studies with significant heterogeneities. RESULTS: Overall, 12 studies concerning GLUT 1 and 2 studies concerning GLUT 3, which involved 2008 participants when combined, were included in this analysis. We found that overexpression of GLUTs were significantly correlated to poorer survival rates (HR=1.63, 95%CI=1.09-2.44 and HR=1.89, 95%CI=1.28-2.81). In the subgroup analysis, the GLUT 1 up-regulation was correlated with negative overall survival in pancreatic cancer and gastric cancer and with better overall survival in colorectal cancer. In addition, overexpression of GLUT 1 was associated with a poorer prognosis in the Asian population, while no significance was found in the non-Asian subgroup. However, limitations do exist, which could be handled better. CONCLUSIONS: A combination of GLUTs 1 and 3 might help predict malignancy of cancers and direct effective cancer therapy. Impact Journals LLC 2017-01-10 /pmc/articles/PMC5355089/ /pubmed/28086215 http://dx.doi.org/10.18632/oncotarget.14570 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chen, Xiu
Lu, Peng
Zhou, Siying
Zhang, Lei
Zhao, Jian-hua
Tang, Jin-hai
Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
title Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
title_full Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
title_fullStr Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
title_full_unstemmed Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
title_short Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
title_sort predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355089/
https://www.ncbi.nlm.nih.gov/pubmed/28086215
http://dx.doi.org/10.18632/oncotarget.14570
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