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Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis
BACKGROUND AND OBJECTIVE: The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker. METHODS: We systemati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355089/ https://www.ncbi.nlm.nih.gov/pubmed/28086215 http://dx.doi.org/10.18632/oncotarget.14570 |
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author | Chen, Xiu Lu, Peng Zhou, Siying Zhang, Lei Zhao, Jian-hua Tang, Jin-hai |
author_facet | Chen, Xiu Lu, Peng Zhou, Siying Zhang, Lei Zhao, Jian-hua Tang, Jin-hai |
author_sort | Chen, Xiu |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker. METHODS: We systematically searched the PubMed, EMbase and Medline databases for relevant published studies that were consistent with the eligible criteria up to January 2016, and calculated pooled estimated hazard ratios of GLUT-1 and -3′s expressions in different cancer types and ethnic populations. Random-effects models were used to assess estimates from studies with significant heterogeneities. RESULTS: Overall, 12 studies concerning GLUT 1 and 2 studies concerning GLUT 3, which involved 2008 participants when combined, were included in this analysis. We found that overexpression of GLUTs were significantly correlated to poorer survival rates (HR=1.63, 95%CI=1.09-2.44 and HR=1.89, 95%CI=1.28-2.81). In the subgroup analysis, the GLUT 1 up-regulation was correlated with negative overall survival in pancreatic cancer and gastric cancer and with better overall survival in colorectal cancer. In addition, overexpression of GLUT 1 was associated with a poorer prognosis in the Asian population, while no significance was found in the non-Asian subgroup. However, limitations do exist, which could be handled better. CONCLUSIONS: A combination of GLUTs 1 and 3 might help predict malignancy of cancers and direct effective cancer therapy. |
format | Online Article Text |
id | pubmed-5355089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53550892017-04-15 Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis Chen, Xiu Lu, Peng Zhou, Siying Zhang, Lei Zhao, Jian-hua Tang, Jin-hai Oncotarget Research Paper BACKGROUND AND OBJECTIVE: The role of glucose transporters in cancers remains contradictory. We conducted a systematic review and meta-analysis to assess the association between overall survival and glucose transporter s (GLUTs) 1 and 3 to find an accurate prognostic biomarker. METHODS: We systematically searched the PubMed, EMbase and Medline databases for relevant published studies that were consistent with the eligible criteria up to January 2016, and calculated pooled estimated hazard ratios of GLUT-1 and -3′s expressions in different cancer types and ethnic populations. Random-effects models were used to assess estimates from studies with significant heterogeneities. RESULTS: Overall, 12 studies concerning GLUT 1 and 2 studies concerning GLUT 3, which involved 2008 participants when combined, were included in this analysis. We found that overexpression of GLUTs were significantly correlated to poorer survival rates (HR=1.63, 95%CI=1.09-2.44 and HR=1.89, 95%CI=1.28-2.81). In the subgroup analysis, the GLUT 1 up-regulation was correlated with negative overall survival in pancreatic cancer and gastric cancer and with better overall survival in colorectal cancer. In addition, overexpression of GLUT 1 was associated with a poorer prognosis in the Asian population, while no significance was found in the non-Asian subgroup. However, limitations do exist, which could be handled better. CONCLUSIONS: A combination of GLUTs 1 and 3 might help predict malignancy of cancers and direct effective cancer therapy. Impact Journals LLC 2017-01-10 /pmc/articles/PMC5355089/ /pubmed/28086215 http://dx.doi.org/10.18632/oncotarget.14570 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Chen, Xiu Lu, Peng Zhou, Siying Zhang, Lei Zhao, Jian-hua Tang, Jin-hai Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis |
title | Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis |
title_full | Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis |
title_fullStr | Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis |
title_full_unstemmed | Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis |
title_short | Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis |
title_sort | predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355089/ https://www.ncbi.nlm.nih.gov/pubmed/28086215 http://dx.doi.org/10.18632/oncotarget.14570 |
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