Cargando…

Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome

Expression of type 5 phosphodiesterase (PDE5), a cGMP-specific hydrolytic enzyme, is frequently altered in human cancer, but its specific role in tumorigenesis remains controversial. Herein, by analyzing a cohort of 69 patients affected by glioblastoma multiforme (GBM) who underwent chemo- and radio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cesarini, Valeriana, Martini, Maurizio, Vitiani, Lucia Ricci, Gravina, Giovanni Luca, Agostino, Silvia Di, Graziani, Grazia, D'Alessandris, Quintino Giorgio, Pallini, Roberto, Larocca, Luigi M, Rossi, Pellegrino, Jannini, Emmanuele A, Dolci, Susanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355091/ https://www.ncbi.nlm.nih.gov/pubmed/28099939 http://dx.doi.org/10.18632/oncotarget.14656

Ejemplares similares

Biomarkers for glioblastoma multiforme: status quo
por: Montano, Nicola, et al.
Publicado: (2016)

Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease
por: Cesarini, Valeriana, et al.
Publicado: (2020)

VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma
por: Martini, Maurizio, et al.
Publicado: (2018)

Brain Invasion along Perivascular Spaces by Glioma Cells: Relationship with Blood–Brain Barrier
por: Pacioni, Simone, et al.
Publicado: (2019)

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis
por: Buccarelli, Mariachiara, et al.
Publicado: (2018)

Glioblastoma endothelium drives bevacizumab‐induced infiltrative growth via modulation of PLXDC1
por: Falchetti, Maria Laura, et al.
Publicado: (2018)

A three‐microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes
por: Marziali, Giovanna, et al.
Publicado: (2017)

Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice
por: Ceruti, Tommaso, et al.
Publicado: (2022)

Dilation of Brain Veins and Perivascular Infiltration by Glioblastoma Cells in an In Vivo Assay of Early Tumor Angiogenesis
por: D'Alessandris, Quintino Giorgio, et al.
Publicado: (2021)

Short tandem repeat profiling for the authentication of cancer stem‐like cells
por: Visconti, Paola, et al.
Publicado: (2020)

Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms
por: Cesarini, Valeriana, et al.
Publicado: (2019)

FMRP modulates the Wnt signalling pathway in glioblastoma
por: Pedini, Giorgia, et al.
Publicado: (2022)

Glioblastoma Stem-Like Cells (GSCs) with Mesenchymal Signature: Lipid Profiles of Mobile Lipids Obtained with MRS before and after Radio/Chemical Treatments
por: Grande, Sveva, et al.
Publicado: (2022)

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome
por: Marziali, G., et al.
Publicado: (2016)

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth
por: Buccarelli, Mariachiara, et al.
Publicado: (2021)

Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts
por: Pacioni, Simone, et al.
Publicado: (2017)

Effects of the Combined Treatment with a G-Quadruplex-Stabilizing Ligand and Photon Beams on Glioblastoma Stem-like Cells: A Magnetic Resonance Study
por: Palma, Alessandra, et al.
Publicado: (2021)

Characterization of Glioblastoma Cells Response to Regorafenib
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2022)

Deregulated expression of the imprinted DLK1-DIO3 region in glioblastoma stemlike cells: tumor suppressor role of lncRNA MEG3
por: Buccarelli, Mariachiara, et al.
Publicado: (2020)

Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
por: Lauretti, Liverana, et al.
Publicado: (2022)

Neuromodulation for Brain Tumors: Myth or Reality? A Narrative Review
por: D’Alessandris, Quintino Giorgio, et al.
Publicado: (2023)

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology
por: Tate, Courtney M., et al.
Publicado: (2015)

Dissecting Stemness in Aggressive Intracranial Meningiomas: Prognostic Role of SOX2 Expression
por: Di Bonaventura, Rina, et al.
Publicado: (2022)

Needs and Expectations of Patients with Erectile Dysfunction: An Update on Pharmacological Innovations in Phosphodiesterase Type 5 Inhibition with Focus on Sildenafil
por: Jannini, Emmanuele A., et al.
Publicado: (2018)

Paths of Evolution of Progressive Anaplastic Meningiomas: A Clinical and Molecular Pathology Study
por: Di Bonaventura, Rina, et al.
Publicado: (2023)

The Role of the “Anti-Inflammatory” Couple for the Management of Hyperuricemia With Deposition
por: Sansone, Andrea, et al.
Publicado: (2022)

Surgical and Clinical Outcomes of Microvascular Decompression: A Comparative Study between Young and Elderly Patients
por: Menna, Grazia, et al.
Publicado: (2022)

The importance of pre-operative neuroanatomical study in the surgical treatment of trigeminal neuralgia associated with multiple sclerosis
por: Montano, Nicola, et al.
Publicado: (2023)

The role of artificial intelligence in the management of trigeminal neuralgia
por: Battistelli, Marco, et al.
Publicado: (2023)

Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1
por: Lulli, Valentina, et al.
Publicado: (2020)

5-Aminolevulinic Acid (5-ALA)-Induced Protoporphyrin IX Fluorescence by Glioma Cells—A Fluorescence Microscopy Clinical Study
por: Pacioni, Simone, et al.
Publicado: (2022)

Treatment of Clival Chordomas: A 20-Year Experience and Systematic Literature Review
por: Noya, Carolina, et al.
Publicado: (2023)

EDEUS, a Real-Life Study on the Users of Phosphodiesterase Type 5 Inhibitors: Prevalence, Perceptions, and Health Care-Seeking Behavior Among European Men With a Focus on 2nd-Generation Avanafil
por: Corona, Giovanni, et al.
Publicado: (2017)

Decompression with or without Fusion for Lumbar Synovial Cysts—A Systematic Review and Meta-Analysis
por: Benato, Alberto, et al.
Publicado: (2023)

Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
por: Tentori, Lucio, et al.
Publicado: (2014)

Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts
por: Pacioni, Simone, et al.
Publicado: (2015)

Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
por: Sighel, Denise, et al.
Publicado: (2021)

Ontogenetic Profile of the Expression of Thyroid Hormone Receptors in Rat and Human Corpora Cavernosa of the Penis
por: Carosa, Eleonora, et al.
Publicado: (2010)

Clinical and NGS predictors of response to regorafenib in recurrent glioblastoma
por: Chiesa, Silvia, et al.
Publicado: (2022)

Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs
por: Grande, Sveva, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_r2uhjt9o15bo2idmfqj5nrh5ou