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The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1
We previously reported the role of cancer/testis antigen CAGE in the response to anti-cancer drugs. CAGE increased the expression of cyclinD1, and pGSK3β(Ser9), an inactive GSK3β, while decreasing the expression of phospho-cyclinD1Thr(286). CAGE showed binding to GSK3β and the domain of CAGE (amino...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355126/ https://www.ncbi.nlm.nih.gov/pubmed/28099142 http://dx.doi.org/10.18632/oncotarget.14621 |