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Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
CD103 is the α(E) subunit of α(E)β(7) integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors. However, little is known about its expression or clinicopathological implications in non-small cell lung cancer (NSCLC). This study investi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355136/ https://www.ncbi.nlm.nih.gov/pubmed/28099920 http://dx.doi.org/10.18632/oncotarget.14632 |
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author | Koh, Jaemoon Kim, Sehui Kim, Moon-Young Go, Heounjeong Jeon, Yoon Kyung Chung, Doo Hyun |
author_facet | Koh, Jaemoon Kim, Sehui Kim, Moon-Young Go, Heounjeong Jeon, Yoon Kyung Chung, Doo Hyun |
author_sort | Koh, Jaemoon |
collection | PubMed |
description | CD103 is the α(E) subunit of α(E)β(7) integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors. However, little is known about its expression or clinicopathological implications in non-small cell lung cancer (NSCLC). This study investigated the prognostic implications of CD103(+) tumor-infiltrating lymphocytes (TILs) in NSCLC. We established two cohorts: patients with resected NSCLC (n = 132) and patients with pulmonary squamous cell carcinoma (pSCC), a subset of NSCLC (n = 378), to estimate the prognostic significance of CD103(+) TILs. The numbers of CD103(+) TILs in the intratumoral (i.e., intraepithelial) and stromal regions of NSCLC were estimated using immunohistochemistry and automated image analysis. In the NSCLC cohort, high numbers of intratumoral CD103(+) TILs were significantly associated with prolonged disease-free survival (DFS) and overall survival (OS) in patients with pSCC but not in those with pulmonary adenocarcinoma. In the pSCC cohort, a positive correlation was observed between the numbers of intratumoral CD103(+) and CD8(+) TILs (correlation coefficient = 0.736, P < 0.001). The ratio of intratumoral/stromal CD103(+) TILs was higher in pSCC with high compared to low E-cadherin expression (P = 0.021). According to Kaplan-Meier analysis, high intratumoral but not stromal CD103(+) TILs were associated with prolonged DFS and OS in patients with resected pSCC (P = 0.021 and 0.002, respectively). Multivariate analysis revealed that a high number of intratumoral CD103(+) TILs is an independent predictor of a more favorable DFS (P = 0.021). Thus, a high number of intratumoral CD103(+) TILs is a favorable prognostic indicator in patients with pSCC. |
format | Online Article Text |
id | pubmed-5355136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53551362017-04-15 Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma Koh, Jaemoon Kim, Sehui Kim, Moon-Young Go, Heounjeong Jeon, Yoon Kyung Chung, Doo Hyun Oncotarget Research Paper CD103 is the α(E) subunit of α(E)β(7) integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors. However, little is known about its expression or clinicopathological implications in non-small cell lung cancer (NSCLC). This study investigated the prognostic implications of CD103(+) tumor-infiltrating lymphocytes (TILs) in NSCLC. We established two cohorts: patients with resected NSCLC (n = 132) and patients with pulmonary squamous cell carcinoma (pSCC), a subset of NSCLC (n = 378), to estimate the prognostic significance of CD103(+) TILs. The numbers of CD103(+) TILs in the intratumoral (i.e., intraepithelial) and stromal regions of NSCLC were estimated using immunohistochemistry and automated image analysis. In the NSCLC cohort, high numbers of intratumoral CD103(+) TILs were significantly associated with prolonged disease-free survival (DFS) and overall survival (OS) in patients with pSCC but not in those with pulmonary adenocarcinoma. In the pSCC cohort, a positive correlation was observed between the numbers of intratumoral CD103(+) and CD8(+) TILs (correlation coefficient = 0.736, P < 0.001). The ratio of intratumoral/stromal CD103(+) TILs was higher in pSCC with high compared to low E-cadherin expression (P = 0.021). According to Kaplan-Meier analysis, high intratumoral but not stromal CD103(+) TILs were associated with prolonged DFS and OS in patients with resected pSCC (P = 0.021 and 0.002, respectively). Multivariate analysis revealed that a high number of intratumoral CD103(+) TILs is an independent predictor of a more favorable DFS (P = 0.021). Thus, a high number of intratumoral CD103(+) TILs is a favorable prognostic indicator in patients with pSCC. Impact Journals LLC 2017-01-10 /pmc/articles/PMC5355136/ /pubmed/28099920 http://dx.doi.org/10.18632/oncotarget.14632 Text en Copyright: © 2017 Koh et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Koh, Jaemoon Kim, Sehui Kim, Moon-Young Go, Heounjeong Jeon, Yoon Kyung Chung, Doo Hyun Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
title | Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
title_full | Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
title_fullStr | Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
title_full_unstemmed | Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
title_short | Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
title_sort | prognostic implications of intratumoral cd103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355136/ https://www.ncbi.nlm.nih.gov/pubmed/28099920 http://dx.doi.org/10.18632/oncotarget.14632 |
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