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Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma

CD103 is the α(E) subunit of α(E)β(7) integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors. However, little is known about its expression or clinicopathological implications in non-small cell lung cancer (NSCLC). This study investi...

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Autores principales: Koh, Jaemoon, Kim, Sehui, Kim, Moon-Young, Go, Heounjeong, Jeon, Yoon Kyung, Chung, Doo Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355136/
https://www.ncbi.nlm.nih.gov/pubmed/28099920
http://dx.doi.org/10.18632/oncotarget.14632
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author Koh, Jaemoon
Kim, Sehui
Kim, Moon-Young
Go, Heounjeong
Jeon, Yoon Kyung
Chung, Doo Hyun
author_facet Koh, Jaemoon
Kim, Sehui
Kim, Moon-Young
Go, Heounjeong
Jeon, Yoon Kyung
Chung, Doo Hyun
author_sort Koh, Jaemoon
collection PubMed
description CD103 is the α(E) subunit of α(E)β(7) integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors. However, little is known about its expression or clinicopathological implications in non-small cell lung cancer (NSCLC). This study investigated the prognostic implications of CD103(+) tumor-infiltrating lymphocytes (TILs) in NSCLC. We established two cohorts: patients with resected NSCLC (n = 132) and patients with pulmonary squamous cell carcinoma (pSCC), a subset of NSCLC (n = 378), to estimate the prognostic significance of CD103(+) TILs. The numbers of CD103(+) TILs in the intratumoral (i.e., intraepithelial) and stromal regions of NSCLC were estimated using immunohistochemistry and automated image analysis. In the NSCLC cohort, high numbers of intratumoral CD103(+) TILs were significantly associated with prolonged disease-free survival (DFS) and overall survival (OS) in patients with pSCC but not in those with pulmonary adenocarcinoma. In the pSCC cohort, a positive correlation was observed between the numbers of intratumoral CD103(+) and CD8(+) TILs (correlation coefficient = 0.736, P < 0.001). The ratio of intratumoral/stromal CD103(+) TILs was higher in pSCC with high compared to low E-cadherin expression (P = 0.021). According to Kaplan-Meier analysis, high intratumoral but not stromal CD103(+) TILs were associated with prolonged DFS and OS in patients with resected pSCC (P = 0.021 and 0.002, respectively). Multivariate analysis revealed that a high number of intratumoral CD103(+) TILs is an independent predictor of a more favorable DFS (P = 0.021). Thus, a high number of intratumoral CD103(+) TILs is a favorable prognostic indicator in patients with pSCC.
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spelling pubmed-53551362017-04-15 Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma Koh, Jaemoon Kim, Sehui Kim, Moon-Young Go, Heounjeong Jeon, Yoon Kyung Chung, Doo Hyun Oncotarget Research Paper CD103 is the α(E) subunit of α(E)β(7) integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors. However, little is known about its expression or clinicopathological implications in non-small cell lung cancer (NSCLC). This study investigated the prognostic implications of CD103(+) tumor-infiltrating lymphocytes (TILs) in NSCLC. We established two cohorts: patients with resected NSCLC (n = 132) and patients with pulmonary squamous cell carcinoma (pSCC), a subset of NSCLC (n = 378), to estimate the prognostic significance of CD103(+) TILs. The numbers of CD103(+) TILs in the intratumoral (i.e., intraepithelial) and stromal regions of NSCLC were estimated using immunohistochemistry and automated image analysis. In the NSCLC cohort, high numbers of intratumoral CD103(+) TILs were significantly associated with prolonged disease-free survival (DFS) and overall survival (OS) in patients with pSCC but not in those with pulmonary adenocarcinoma. In the pSCC cohort, a positive correlation was observed between the numbers of intratumoral CD103(+) and CD8(+) TILs (correlation coefficient = 0.736, P < 0.001). The ratio of intratumoral/stromal CD103(+) TILs was higher in pSCC with high compared to low E-cadherin expression (P = 0.021). According to Kaplan-Meier analysis, high intratumoral but not stromal CD103(+) TILs were associated with prolonged DFS and OS in patients with resected pSCC (P = 0.021 and 0.002, respectively). Multivariate analysis revealed that a high number of intratumoral CD103(+) TILs is an independent predictor of a more favorable DFS (P = 0.021). Thus, a high number of intratumoral CD103(+) TILs is a favorable prognostic indicator in patients with pSCC. Impact Journals LLC 2017-01-10 /pmc/articles/PMC5355136/ /pubmed/28099920 http://dx.doi.org/10.18632/oncotarget.14632 Text en Copyright: © 2017 Koh et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Koh, Jaemoon
Kim, Sehui
Kim, Moon-Young
Go, Heounjeong
Jeon, Yoon Kyung
Chung, Doo Hyun
Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
title Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
title_full Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
title_fullStr Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
title_full_unstemmed Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
title_short Prognostic implications of intratumoral CD103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
title_sort prognostic implications of intratumoral cd103(+) tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355136/
https://www.ncbi.nlm.nih.gov/pubmed/28099920
http://dx.doi.org/10.18632/oncotarget.14632
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