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MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

We established an in vitro cell culture system to determine novel activities of the retinoblastoma (Rb) protein during tumor progression. Rb depletion in p53-null mouse-derived soft tissue sarcoma cells induced a spherogenic phenotype. Cells retrieved from Rb-depleted spheres exhibited slower prolif...

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Detalles Bibliográficos
Autores principales:	Yoshida, Akiyo, Kitajima, Shunsuke, Li, Fengkai, Cheng, Chaoyang, Takegami, Yujiro, Kohno, Susumu, Wan, Yuan Song, Hayashi, Naoyuki, Muranaka, Hayato, Nishimoto, Yuuki, Nagatani, Naoko, Nishiuchi, Takumi, Thai, Tran C, Suzuki, Sawako, Nakao, Shinji, Tanaka, Tomoaki, Hirose, Osamu, Barbie, David A., Takahashi, Chiaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355146/ https://www.ncbi.nlm.nih.gov/pubmed/28099924 http://dx.doi.org/10.18632/oncotarget.14681

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