Cargando…
Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women
OBJECT: Hyaluronic acid binding protein 1 (HABP1/p32/gC1qR) is overexpressed in breast cancer. However, it is unknown whether HABP1 gene polymorphisms affect breast cancer risk. This study aims to evaluate the potential association of single nucleotide polymorphisms (SNPs) of HABP1 with breast cance...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355151/ https://www.ncbi.nlm.nih.gov/pubmed/28108744 http://dx.doi.org/10.18632/oncotarget.14737 |
_version_ | 1782515480791089152 |
---|---|
author | Jiang, Yongdong Wu, Hao Liu, Jing Chen, Yanbo Xie, Jingjing Zhao, Yashuang Pang, Da |
author_facet | Jiang, Yongdong Wu, Hao Liu, Jing Chen, Yanbo Xie, Jingjing Zhao, Yashuang Pang, Da |
author_sort | Jiang, Yongdong |
collection | PubMed |
description | OBJECT: Hyaluronic acid binding protein 1 (HABP1/p32/gC1qR) is overexpressed in breast cancer. However, it is unknown whether HABP1 gene polymorphisms affect breast cancer risk. This study aims to evaluate the potential association of single nucleotide polymorphisms (SNPs) of HABP1 with breast cancer in northern Chinese women. RESULTS: The minor allele of rs2285747 was strongly associated with breast cancer with OR of 1.553 (95% CI = 1.251–1.927). SNP rs2285747 was also associated with high HABP1 protein expression under the co-dominant and dominant model (p = 0.005, p = 0.019, respectively). For rs2472614, the patients with CG and GG were more likely to have HER2 negative tumors compared to CC (p = 0.015). For rs3786054, the patients with AG and GG were more likely to have HER2 and P53 negative breast cancer compared to AA (p = 0.024, p = 0.064, receptively). MATERIALS AND METHODS: Seven SNPs were analyzed in 505 breast cancer patients and 505 controls using SNaPshot method. The associations between SNPs and breast cancer were examined by logistic regression. The associations of SNPs with HABP1 protein expression and disease characteristics were examined by chi-square test. CONCLUSIONS: SNP rs2285747 of HABP1 increased breast cancer risk and elevated its protein expression in northern Chinese women. |
format | Online Article Text |
id | pubmed-5355151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53551512017-04-15 Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women Jiang, Yongdong Wu, Hao Liu, Jing Chen, Yanbo Xie, Jingjing Zhao, Yashuang Pang, Da Oncotarget Research Paper OBJECT: Hyaluronic acid binding protein 1 (HABP1/p32/gC1qR) is overexpressed in breast cancer. However, it is unknown whether HABP1 gene polymorphisms affect breast cancer risk. This study aims to evaluate the potential association of single nucleotide polymorphisms (SNPs) of HABP1 with breast cancer in northern Chinese women. RESULTS: The minor allele of rs2285747 was strongly associated with breast cancer with OR of 1.553 (95% CI = 1.251–1.927). SNP rs2285747 was also associated with high HABP1 protein expression under the co-dominant and dominant model (p = 0.005, p = 0.019, respectively). For rs2472614, the patients with CG and GG were more likely to have HER2 negative tumors compared to CC (p = 0.015). For rs3786054, the patients with AG and GG were more likely to have HER2 and P53 negative breast cancer compared to AA (p = 0.024, p = 0.064, receptively). MATERIALS AND METHODS: Seven SNPs were analyzed in 505 breast cancer patients and 505 controls using SNaPshot method. The associations between SNPs and breast cancer were examined by logistic regression. The associations of SNPs with HABP1 protein expression and disease characteristics were examined by chi-square test. CONCLUSIONS: SNP rs2285747 of HABP1 increased breast cancer risk and elevated its protein expression in northern Chinese women. Impact Journals LLC 2017-01-19 /pmc/articles/PMC5355151/ /pubmed/28108744 http://dx.doi.org/10.18632/oncotarget.14737 Text en Copyright: © 2017 Jiang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Jiang, Yongdong Wu, Hao Liu, Jing Chen, Yanbo Xie, Jingjing Zhao, Yashuang Pang, Da Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women |
title | Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women |
title_full | Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women |
title_fullStr | Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women |
title_full_unstemmed | Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women |
title_short | Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women |
title_sort | increased breast cancer risk with habp1/p32/gc1qr genetic polymorphism rs2285747 and its upregulation in northern chinese women |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355151/ https://www.ncbi.nlm.nih.gov/pubmed/28108744 http://dx.doi.org/10.18632/oncotarget.14737 |
work_keys_str_mv | AT jiangyongdong increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen AT wuhao increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen AT liujing increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen AT chenyanbo increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen AT xiejingjing increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen AT zhaoyashuang increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen AT pangda increasedbreastcancerriskwithhabp1p32gc1qrgeneticpolymorphismrs2285747anditsupregulationinnorthernchinesewomen |