Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens

Effective adoptive immunotherapy has proved elusive for many types of human cancer, often due to difficulties achieving robust expansion of natural tumor-specific T-cells from peripheral blood. We hypothesized that antigen-driven T-cell expansion might best be triggered in vitro by acute activation...

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Detalles Bibliográficos
Autores principales: Pathangey, Latha B., McCurry, Dustin B., Gendler, Sandra J., Dominguez, Ana L., Gorman, Jessica E., Pathangey, Girish, Mihalik, Laurie A., Dang, Yushe, Disis, Mary L., Cohen, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355224/
https://www.ncbi.nlm.nih.gov/pubmed/27974697
http://dx.doi.org/10.18632/oncotarget.13911

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