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Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells

The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death in hematopoietic cancer cells with high Bcl-xL expression. Here, we demonstr...

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Detalles Bibliográficos
Autores principales:	Zhang, Yu, Li, Xin, Tan, Shisheng, Liu, Xinyu, Zhao, Xinyu, Yuan, Zhu, Nie, Chunlai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355244/ https://www.ncbi.nlm.nih.gov/pubmed/28038464 http://dx.doi.org/10.18632/oncotarget.14223

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