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Combination of Arsenic trioxide and Everolimus (Rad001) synergistically induces both autophagy and apoptosis in prostate cancer cells

The inhibitor of PI3K-AKT-mTOR pathway, such as Rad001, has not shown therapeutic efficacy as a single agent in prostate cancer. Arsenic trioxide induces the autophagic pathway in prostate cancer cells. We identified Arsenic trioxide can synergize with Rad001 to induce cytotoxicity of prostate cance...

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Detalles Bibliográficos
Autores principales:	Tai, Sheng, Xu, Lingfan, Xu, Ming, Zhang, Ligang, Zhang, Yangyang, Zhang, Kaipin, Zhang, Li, Liang, Chaozhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355258/ https://www.ncbi.nlm.nih.gov/pubmed/28061438 http://dx.doi.org/10.18632/oncotarget.14493

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