MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering

The receptor tyrosine kinase MET and its ligand, the hepatocyte growth factor, are essential to embryonic development, whereas deregulation of MET signaling is associated with tumorigenesis leading to various cancers, including lung carcinoma. Mutations in the MET kinase domain lead to constitutive...

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Detalles Bibliográficos
Autores principales: Montagne, Rémi, Baranzelli, Anne, Muharram, Ghaffar, Catherine, Leroy, Lesaffre, Marie, Vinchent, Audrey, Kherrouche, Zoulika, Werkmeister, Elisabeth, Cortot, Alexis B, Tulasne, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355264/
https://www.ncbi.nlm.nih.gov/pubmed/28061464
http://dx.doi.org/10.18632/oncotarget.14499

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