LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter

Lysine-specific demethylase 1 (LSD1), which specifically demethylates histone H3 lysine 4 (H3K4) and lysine 9 (H3K9), is dysregulated in several cancers. We found that ectopic expression of LSD1 in cervical cancer cells promoted invasion and metastasis in vitro and in vivo, reduced the expression of...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Wang, Yanan, Chen, Chunqin, Zhang, Jiawen, Qian, Wenyan, Dong, Yu, Liu, Zhiqiang, Zhang, Xi, Wang, Xiaoyun, Zhang, Zhenbo, Shi, Xiaobing, Wu, Sufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355268/
https://www.ncbi.nlm.nih.gov/pubmed/27894088
http://dx.doi.org/10.18632/oncotarget.13516

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